Interferon-gamma (IFNG) drives regulatory T cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancer

Immunotherapy – drug therapy that stimulates the immune system to attack tumors – has a good effect on some types of cancer, but its effect on lung cancer is mixed.   A new study helps to clarify why the immune system responds so weakly to lung cancer, even after treatment with immunotherapy drugs. In this study on mice, researchers from the Massachusetts Institute of Technology found that bacteria found naturally…

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In SARS-CoV-2 Infection and Cytokine Shock Syndrome, TNF-α and IFN-γ Cause Inflammatory Cell Death, Tissue Damage and Death

The COVID-19 pandemic continues to cause major illness and death, while treatment options are still limited. In a new study, researchers from the St. Jude Children’s Research Hospital in the United States have discovered a potential strategy to prevent life-threatening inflammation, lung damage, and organ failure in COVID-19 patients. The relevant research results were published in the Cell. The title of the paper is “Synergism of TNF-α and IFN-γ triggers…

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