Recently, researchers from Ghent University Hospital in Belgium published an article entitled “A human immune dysfunction syndrome characterized by severe hyperinflammation with a homozygous nonsense roquin-1 mutation” in Nature Communications. By studying a case of the hyperinflammatory syndrome with a homozygous nonsense mutation in Roquin-1, they discovered the mechanism of human immune dysregulation triggered by mutations in Roquin-1 protein, which may provide a new approach for the diagnosis and treatment…