Toll-like receptor 4 (TLR4) is a central regulatory factor of innate immunity in the body, mainly able to recognize the lipopolysaccharide cell wall components of bacteria and induce cytokine release.   Recently, a research report titled “RHBDL4-triggered downregulation of COPII adaptor protein TMED7 suppresses TLR4-mediated inflammatory signaling” was published in Nature Communications. Scientists from institutions such as the University of Cologne found through their research that the membrane protease RHBDL4…