During antiretroviral therapy, the persistent presence of HIV-1 may be due to its establishment of a long-lived virus library in quiescent immune cells. Recently, an article titled “TGF-β blockade drives a transitional effector phenotype in T cells reversing SIV latency and decreasing SIV reservoirs in vivo” was published in the international journal Nature Communications. In the research report, scientists from institutions such as Northwestern University in the United States used…
TGFβ
CXCL12-CXCR4/CXCR7, Two Axes to Repress Breast Cancer
Recently, there are two articles which reported the study on CXCL12 and breast cancer. Let’s take a glance on these new results. Breast cancer (BC) remains the most frequent cancer and the major cause of cancer-associated death in women. Based on histopathological analysis commonly used in clinical practice, BC has been identified as a heterogeneous disease classified into three main subtypes: Luminal (Lum), HER2 and triple-negative (TN), which have been…