Research Progress on Structural Characteristics and Enzyme Activity Regulation Mechanisms of Viral Topoisomerases

Recently, Deng Zengqin’s team from the Chinese Academy of Sciences Wuhan Virus Research Institute/Antiviral Research Center completed the latest research achievement entitled “Structure-function analysis of the ATPase domain of African swine fever virus topoisomerase”, which was published online on mBio.   DNA topoisomerases are widely present in archaea, prokaryotes, eukaryotes, and some nuclear-cytoplasmic large DNA viruses, playing important roles in gene replication, transcription, recombination, and chromosome separation processes. DNA topoisomerase…

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