JCI: STAT3 Inhibitor May Provide New Hope for Leukemia Treatment

Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are malignant hematopoietic stem cell disorders, and abnormal stem cell populations in hematopoietic stem and progenitor cells can cause disease. Traditional treatments to date can not completely eliminate these abnormal hematopoietic stem cells associated with the disease.   Recently, researchers from the Albert Einstein College of Medicine have discovered a prognosis molecule that predicts both MDS and AML. Furthermore, an antisense oligonucleotide…

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New Drug Targets That Are Expected to Treat Malignant Cancer Discovered

Recently, scientists from the Dana-Farber Cancer Institute have discovered new drug targets for two malignant cancers. It is expected to develop new therapies for the treatment of synovial sarcoma and malignant rods-shaped tumors. Related research result was published in the Nature Cell Biology.   The researchers say that these two cancers depend on a new molecular called ncBAF, which plays a key role in regulating gene activity, consisting of multiple specific…

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Herpes Virus Is One of the Causes of Alzheimer’s Disease!

Alzheimer’s disease is one of the most common forms of dementia. More than 30 million people worldwide suffer from Alzheimer’s disease. Unfortunately, there is currently no cure for the disease, only drugs that relieve the symptoms of the patient; in a recently published dissertation, the author (Professor Ruth Itzhaki of the University of Manchester) proposed a new method for the treatment of Alzheimer’s disease. The researchers pointed out that some…

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Progress in HIV Research in October 2018 (II)

(…Continued)   JCI: Infectious HIV is not present in liver macrophages of HIV-infected patients receiving treatment doi:10.1172/JCI121678   In a new study, researchers from Johns Hopkins University and Los Alamos National Laboratory determined whether liver macrophages are infectious HIV-1 virus pools after ART treatment. The real source of the liver tissue samples from nine HIV-1 infected individuals (7 of them were transplanted at Johns Hopkins Hospital). Eight of these nine…

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Progress in HIV Research in October 2018 (I)

Human immunodeficiency virus (HIV), an AIDS (AIDS, acquired immunodeficiency syndrome) virus, is a virus that causes defects in the human immune system. In 1983, HIV was first discovered in the United States. It is a lentivirus that infects cells of the human immune system and is a type of retrovirus. By destroying the body’s T lymphocytes, HIV blocks cellular and humoral immune processes, causing the immune system to deficiency, and…

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BCR: Targeting Collagen XIII Protein Is Expected to Successfully Treat Breast Cancer Metastasis

Recently, researchers from the University of Kentucky found that targeting a protein called collagen XIII  may effectively inhibit the metastasis of breast cancer. And the article related was published on Breast Cancer Research.   Breast cancer begins in epithelial cells, cells that are arranged in organs and tissues of the body. In general, most of the epithelial cells die when detached from the extracellular matrix. This type of programmed cell…

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Cancer Res: Cancer Stem Cells May Use Normal Genes to “Do Evil”

CDK1 is a normal protein that drives cells through the replication cycle, while MHC class 1 molecule is also a normal molecule that exhibits a small amount of protein on the cell surface for examination by the immune system; Recently, scientists from the University of Colorado Cancer Center found that a group of cancer cells labeled with MHC class 1 molecule and high levels of CDK1 are extremely unusual. In…

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Nature: “Reconstruct” T cells into the Brain and Attack “Escape” Cancer Cells

For glioblastoma, immunotherapy faces a particular challenge—the blood-brain barrier blocks T cells from entering the brain to prevent brain inflammation that can be life-threatening. This “protective measure” is beneficial under normal conditions, but it prevents T cells from reaching the glioblastoma, leaving immunotherapy useless.   On September 5th, Nature published an article entitled “A homing system targets therapeutic T cells to brain cancer”, which reveals a new solution from a…

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PCGF5 Is Required for Neural Differentiation of Embryonic Stem Cells

Researcher Yao Hongjie from the Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences published a research report entitled “PCGF5 is required for neural differentiation of embryonic stem cells” on Nature Communications. This work reveals the molecular mechanism by which polycomb PCGF5 regulates the differentiation of embryonic stem cells into neural precursor cells.   Epigenetic modification plays an important role in maintaining stem cell characteristics and cell fate transformation….

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New Mechanism by Which Cancer Cells Inhibit Anti-tumor Immune Responses Revealed

Cancer cells are not just a group of cells that are out of control; for their own survival, they actively participate in the struggle with the immune system. Being able to evade detection by the immune system is a feature of cancer. In a new study, researchers from the University of Pennsylvania found that cancer cells release biological “unmanned aerial vehicles” – small vesicles called exosomes that circulate in the…

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