Cell division is the most important and common events in life. However, the entire mechanism of cell division is still mysterious for us. Recently, scientists (Carlos Garzon-Coral, Horatiu A. Fantana, Jonathon Howard) found A force-generating machinery that can maintain the spindle at the cell center during mitosis, and they published their findings on Science Magazine (Science 27 May 2016: Vol. 352, Issue 6289, pp. 1124-1127 DOI: 10.1126/science.aad9745). Here, let us…
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Tau Protein—Not Amyloid—May Be Key Driver of Alzheimer’s Symptoms
Tau proteins are the product of alternative splicing from a single gene, which in humans is designated MAPT (microtubule-associated protein tau) and is located on chromosome 17. They were discovered in 1975 in Marc Kirschner’s laboratory at Princeton University. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. Pathologies and dementias of the nervous system such as Alzheimer’s disease and Parkinson’s disease are associated with tau…
JAK2 Inhibitors Target Aggressive Breast Cancers
Janus kinase 2 (commonly called JAK2) is a non-receptor tyrosine kinase. It is a member of the Janus kinase family and has been implicated in signaling by members of the type II cytokine receptor family (e.g. interferon receptors). Here we’d like to share a latest research about JAK2 gene in breast cancer. This article comes from www.sciencemag.org and www.ScienceTranslationalMedicine.org and you can get all detail from these sites. what’s more,…
Antidepressant Target-Serotonin Transporter Reveals Its Shape
Prozac and its kin — drugs called selective serotonin reuptake inhibitors (SSRIs) — were first discovered in 1972. They address one hallmark of depression: low levels of the molecule serotonin, which neurons use to signal one another. By preventing a protein called serotonin transporter (SERT) form absorbing the serotonin back into neurons that release it, the drugs boost serotonin levels in the junctions between cells. It is exciting that the…
Chromatin immunoprecipitation (ChIP): For DNA Binding Proteins and DNA Binding Sites Analysis
Chromatin immunoprecipitation followed by sequencing (ChIP-Seq) is a well-established method for identifying binding sites for DNA-binding proteins. This method involves (1) cross-linkage of DNA binding proteins to DNA, (2) DNA shearing, (3) immunoprecipitation of DNA fragments bound by a protein of interest, and (4) sequencing of precipitated DNA fragments. Resulting sequencing reads are aligned to the corresponding genome, and genome areas bound by the protein of interest are expected to…
Protein Crystallography: From Protein Structure to Protein Function
The function of a protein is encoded by its 3D structure. Protein crystallography is used as the major biophysical approach to investigate protein structure and function. A world class protein crystallography facility together with a high throughput protein expression facility for protein structure determination can be used to examine proteins of prime importance to human health. The recent advances in molecular medicine have led to an increase in the demand…
Cytokine and Receptor Analysis in Creative BioMart
Cytokine receptors are receptors that bind cytokines. In recent years, cytokine receptors have caught much more attentions than cytokines themselves. Maybe this is because of their remarkable characteristics or because a deficiency of cytokine receptors has now been directly linked to certain debilitating immunodeficiency states. Creative BioMart, a world leading biotech company dedicated to providing quality custom analytical and translational services, has a revolutionary new platform designed for enrichment and highly…
Probe into Discovery and Translational Service in Creative BioMart
Creative BioMart, a leader in protein accelerated protein discovery and translational services with expertise and robust facilities for protein array, epitope mapping and radioimmunoassays, is excellent in the field of protein based lead discovery. Let the writer lead you to Creative BioMart’s Discovery and Translational Services: Biomarker Service To support the customers’ needs for drug development, Creative BioMart provides a wide range of biomarker assay development and validation services as…