Ellefson et al. construct a reverse transcriptase using in vitro directed evolution and protein engineering from a prokaryotic DNA polymerase. This reverse transcriptase shows increased fidelity as compared to natural reverse transcriptases and increases the precision of transcriptomics methods. Ellefson et al. published their results in Science Magazine (Science 24 Jun 2016: Vol. 352, Issue 6293, pp. 1590-1593 DOI: 10.1126/science.aaf5409). The article is followed: The molecular basis for life rests on the information flow…