The correct positioning of membrane proteins on the corresponding organelles is important for maintaining the specific “identity” and physiological functions of the organelles. The correct positioning of membrane proteins relies on precise protein sorting pathways and requires corresponding mechanisms on organelles to eliminate mislocated proteins. For example, the AAA-ATPase Msp1 of the outer mitochondrial membrane can remove the protein that is incorrectly located on the outer mitochondrial membrane. However, what…
Month: November 2020
In SARS-CoV-2 Infection and Cytokine Shock Syndrome, TNF-α and IFN-γ Cause Inflammatory Cell Death, Tissue Damage and Death
The COVID-19 pandemic continues to cause major illness and death, while treatment options are still limited. In a new study, researchers from the St. Jude Children’s Research Hospital in the United States have discovered a potential strategy to prevent life-threatening inflammation, lung damage, and organ failure in COVID-19 patients. The relevant research results were published in the Cell. The title of the paper is “Synergism of TNF-α and IFN-γ triggers…