The development of normal mammals occurs in a hydrogen-peroxide environment, and the adaptive response to hydrogen peroxide is considered a landmark event for embryo survival in hypoxic fallopian tubes and intrauterine environments, thus playing a crucial role in mammalian evolution. Due to the gene deletion of hypoxia-inducible factor (HIF) (oxygen-sensitive transcription factor), the response to physO2 is insufficient, resulting in embryo loss during implantation or severe developmental defects shortly after…
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Key Targets in Molecular Characteristics of Parkinson’s disease at Different Stages of Progression
The neuroinflammation associated with Parkinson’s disease (PD) has attracted widespread attention due to abnormal protein aggregation, among which glycosylation, as a post-translational modification process that maintains protein stability, plays an important role in this process. Recently, in a research report published in the international journal PNAS Nexus titled ” Changes in tissue protein N-glycosylation and associated molecular signature occur in the human Parkinsonian brain in a region-specific manner”, scientists…
The Molecular Mechanism of Fusion Protein Intercepting Gene Regulators and Inducing Childhood Cancer
The occurrence of many childhood cancers often begins with molecular hijacking. Recently, a research report titled “Heterotypic interactions can drive selective co-condensation of prion-like low-complexity domains of FET proteins and mammalian SWI/SNF complex” was published in the journal Nature Communications. Scientists from institutions such as the University of Buffalo revealed through their research how fusion proteins intercept gene regulators to stimulate the development of cancer in children. In the…
The Influence of Age and Number of Mutations on the Size of Clonal Hematopoiesis
Hainan Medical College’s Ren Ruibao, Cai Wangwei, and Shanghai Jiao Tong University’s Chen Zhu jointly published a research paper on PNAS titled “The impact of age and number of mutations on the size of clonal hematopoiesis”, which reported an in-depth analysis of Clonal Hematopoiesis (CH) in the elderly population with longevity (age ≥ 90 years old) and general health (age 60-89 years old). This study utilized targeted deep sequencing and…
Research Progress on Structural Characteristics and Enzyme Activity Regulation Mechanisms of Viral Topoisomerases
Recently, Deng Zengqin’s team from the Chinese Academy of Sciences Wuhan Virus Research Institute/Antiviral Research Center completed the latest research achievement entitled “Structure-function analysis of the ATPase domain of African swine fever virus topoisomerase”, which was published online on mBio. DNA topoisomerases are widely present in archaea, prokaryotes, eukaryotes, and some nuclear-cytoplasmic large DNA viruses, playing important roles in gene replication, transcription, recombination, and chromosome separation processes. DNA topoisomerase…
Genetic Anxiety Switch in the Body
Recently, a research report titled “An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behavior in mice and humans” was published in the journal Molecular Psychology. Scientists from institutions such as the University of Aberdeen found through their research that special DNA regions in the human genome may play an important role in controlling anxiety disorders in the body, this key gene may affect the…
Reveal A New Immune Pathway for The Treatment of Bone Metastasis in Breast Cancer
Immunotherapy is a very promising method for the treatment of metastatic breast cancer, which can provide new possibilities for treatment. Although checkpoint inhibitors show some hope in the treatment of metastatic breast cancer, their therapeutic effect on patients with bone metastases is disappointing. The lack of such efficacy seems to have a certain specificity for the bone environment, which will show the characteristics of avoiding inhibition. Recently, a research report…
The Special Protective Effects of Breast Milk
Breastfeeding can provide significant health benefits for newborns and infants by providing nutrition, immune protection, and shaping the gut microbiota. Although scientists have long believed that breast milk contains complement components, the physiological correlation of complement components in breast milk is not clear to them. Recently, a research report titled “Complement in breast milk modifies offspring gut microbiota to promote infant health ” was published in the journal Cell. Scientists…
Research Progress on the Interaction Mechanism between Bunyavirus and Host
Recently, the team of Wang Hualin, Deng Fei, and Ning Yunjia from the Chinese Academy of Sciences Wuhan Virology Research Institute/National Viral Resource Bank published the research papers titled “Interactome profiling of Crimean-Congo hemorrhagic fever virus glycoproteins” and “Host factor MxA restricts Dabie bandavirus infection by targeting the viral NP protein to inhibit NP-RdRp interaction and ribonucleoprotein activity”. The above research elucidates new interaction mechanisms between the virus and host…
In Situ Regeneration Research of Inner Hair Cells in a Mouse Injury Model Induced By Ectopic Expression of Tbx2 and Atoh1
The Development journal published a research paper online titled “In situ regeneration of inner hair cells in the damaged cochlea by temporally regulated coexpression of Atoh1 and Tbx2”. The research was completed by Liu Zhiyong, a research group of the Center for Excellence and Innovation in Brain Science and Intelligent Technology (Institute of Neuroscience) of the Chinese Academy of Sciences, and the Shanghai Brain Science and Brain Research Center (Shanghai…