The immune system acts as a guardian of the host by initiating an immune response to harmful pathogens and tumor cells. However, overreaction is the cause of chronic or excessive inflammation and autoimmune diseases. Immune checkpoints play a key role in regulating the size of immune responses, thereby maintaining immune homeostasis and self-tolerance. However, tumor cells can also use immune checkpoints to evade immune surveillance, suppress anti-tumor immune responses, and…
Day: March 30, 2023
The Role of the Third Intracellular Ring of GPCR in GPCR Signal Conduction Mechanism
In a new study, American researchers have discovered the role of the third intracellular loop of GPCR in the GPCR signal transduction mechanism, indicating the possibility of adopting more targeted drug discovery methods and developing new drugs. More than one-third of the drugs approved by the United States Food and Drug Administration (FDA) function by targeting G protein-coupled receptors (GPCRs). The human body has over 800 types of GPCRs,…
The Base Editor Is Expected to Be Used for the Treatment of CD3Δ Severe Combined Immunodeficiency
In a new study, researchers from research institutions such as the University of California, Los Angeles, discovered that advanced genome editing technology may be able to be used for a rare and fatal genetic disease, D3 delta severe combined immunodeficiency, CD3δ SCID, for a one-time treatment. The relevant research results were published online in Cell, with the title “Human T cell generation is restored in CD3δ severe combined immunodeficiency through…
Understand the mechanism of action of CFTR to better treat cystic fibrosis
In a new study, researchers from St. Jude’s Children’s Research Hospital and Rockefeller University in the United States combined their expertise to gain a better understanding of a protein called cystic fibrosis transmembrane conductance regulator (CFTR). Mutations in CFTR cause cystic fibrosis, a fatal disease that cannot be cured. The relevant research results were published online in the journal Nature, with the title “CFTR function, physiology and pharmacology at single…