In a new study, professor Virginijus Šikšnys from the Life Sciences Center (VU-LSC) of Vilnius University in Lithuania and his research team cooperated with Professor Guillermo Montoya of the Novo Nordisk Foundation Protein Research Center (CPR) of the University of Copenhagen in Denmark and his research team to determine the structure of TnpB using Cryo-EM. The relevant research results were published in Nature on April 13, 2023, with the title…
Month: May 2023
Scientists Have Screened New Serotonin Transporter Inhibitors From Over 20 Billion Molecules
Highlights •Large-library docking finds conformationally and target-selective SERT inhibitors •Cryo-EM supports the computationally predicted structure •The inhibitors are anti-depressant-like and alleviate opioid withdrawal in mice •Targeting of transporters for structure-based ligand discovery 5-hydroxytryptamine transporter (SERT) is a common target for antidepressants as it can “transport” serotonin from synapses. Transporting protein transporters is a process of “swallowing and vomiting”, completed by alternating protein conformations opening outward and inward. Research…
Insufficient Sleep Can Lead to Dementia, Affecting the Clearance of Toxic Proteins in the Brain and Increasing the Risk of Dementia
This study reveals how sleep deprivation affects microglia, and finds that TREM2 mediates sleep deprivation-induced microglia overactivation, and β-Amyloid protein (Aβ） deposition increases. Long-term chronic sleep deprivation regulates inflammation and the metabolic reaction of microglia and Aβ in the brain. With the accelerating pace of society and increasing work pressure, it is sometimes particularly luxurious for modern people to have a good sleep. However, a large number of studies…
Molecular Mechanism of Melanoma Induced by CDK13 Mutant Protein
The RNA surveillance pathway can detect and interpret defective transcripts to ensure the fidelity of RNA. Recently, in a research report entitled “Oncogenic CDK13 mutations infinite nuclear RNA surveillance” published on the international journal Science, scientists from Howard Hughes Medical Research Institute and other institutions found a new mechanism that affects the occurrence of melanoma through research, which has a very broad and important significance for the treatment of multiple…