Creative Biomart Blog

Tue, 2024/01/02

MSL2 Ensures the Expression Mechanism of Mammalian Biallelic Genes

Have you ever thought about why every chromosome in our cells has two copies? During the breeding process, we obtain a copy from each of our parents. This means that we also obtained two copies or alleles of each gene from each chromosome or pair of parents. Both alleles can produce messenger ribonucleic acid (mRNA), which is the formula required for mRNA to manufacture proteins and maintain cell operation. Scientists assume that each gene has two alleles, which are redundant systems built into cells. If a mutation occurs in an allele on one of the chromosomes or causes a decrease in mRNA p

Mon, 2023/12/04

Themis2 Can Regulate Natural Killer Cell Immune Memory

Immune memory is a hallmark of the adaptive immune system in the body. Although natural killer cells (NK cells) are essential innate immune cells for the host's immediate defense system, they can also differentiate into memory NK cells. Currently, researchers have not fully elucidated the molecular mechanisms behind controlling this differentiation process. Recently, a research report titled “Themis2 regulates natural killer cell memory function and formation” was published in the journal Nature Communications. Scientists from institutions such as the University of Tsukuba in Japan identified

Mon, 2023/12/04

The Regulation of Cancer Stem Cells and Its Implications for Targeted Cancer Therapy

Tumor occurrence and progression are considered to be a complex progressive process involving multi-level reactions and accumulation of mutations. In the past few decades, there have been many studies on this topic in the field of oncology. These studies mainly focus on tumor cells, tumor microenvironment, tumor heterogeneity, etc., among which tumor heterogeneity is closely related to the occurrence and malignancy of tumors. Cancer stem cells (CSCs), as one of the theories explaining the mechanism of tumor heterogeneity, have received widespread attention. Recently, researchers from Sichua

Mon, 2023/12/04

Molecular Mechanism behind MAF Protein Promoting Breast Cancer Metastasis

Breast cancer is the most common type of cancer among women. There are more than 2 million new cases of breast cancer every year. The survival rate of patients is very high, about 90%, when the tumor is still limited to breast tissue; however, when cancer cells spread beyond breast tissue and begin to form metastases in other organs, it significantly worsens the patient's prognosis and poses great challenges to their treatment. In previous studies, researchers believed that MAF protein was directly related to the increased risk of breast cancer metastasis, but the reason behind the association

Mon, 2023/12/04

CDK4 Is Expected To Be Used In the Treatment of Type 2 Diabetes

Type 2 diabetes affects more than 500 million people worldwide. In a new study, researchers from Weill Cornell Medical College in the United States found a new pathway that stimulates insulin production in the preclinical diabetes model for healthy pancreas β cell growth. This discovery brings hope for future treatment, which will improve the life of patients with type 2 diabetes. The relevant research results have recently been published in the Journal of Clinical Investigation, titled “Noncanonical CDK4 signaling rescues diabetes in a mouse model by promoting β cell differentiation”. Dr.

Sat, 2023/11/04

PLSCR1 Is a Cellular Autonomous Defense Factor That Resists SARS-Cov-2 Infection

Earlier this month, multiple health departments confirmed that BA.2.86- a highly mutated SARS-CoV-2 virus that causes COVID-19- poses a risk of rapid transmission in countries around the world. This week, the latest vaccination plan will be launched across the United States, but it remains to be seen whether this latest vaccination plan will effectively slow down the spread of BA.2.86 or other new virus variants. However, vaccines remain the most powerful treatment tool for preventing and slowing down the spread of COVID-19. However, in a new study, researchers from Yale University in the U

Sat, 2023/11/04

Discovering New Protein Families and Folds Using Artificial Intelligence Tools

In a new study, researchers from the Swiss Institute of Bioinformatics and the University of Basel have discovered a treasure trove of uncharacterized proteins. In the recent deep learning revolution, they have discovered hundreds of new protein families and even a new predictive protein fold. The relevant research results were published online in the journal Nature, with the title “Uncovering new families and folds in the natural protein universe”. In the past few years, AlphaFold has brought revolutionary changes to protein science. This artificial intelligence (AI) tool is trained based

Sat, 2023/11/04

DCC May Help Identify Human Parkinson's Disease

At present, the diagnosis of Parkinson's disease is mainly based on clinical standards, but the sensitivity of clinical standards is often limited before most dopaminergic neurons are lost. Recently, in a research report published in Nature Aging titled “DOPA decarboxylase is an emerging biomarker for Parkinsonian disorders including preclinical Lewy body disease”, scientists from institutions such as the Caroline College in Sweden found through research that, the levels of the marker DOPA decarboxylase (DCC) in Parkinson's disease patients and other diseases that cause dopamine deficiency in