Creative Biomart Blog

Fri, 2024/11/15

New Mechanism of ACLY Regulating Thermogenesis and Metabolic Stress in Brown Adipose Tissue

Brown adipose tissue (BAT) plays an important role in mammalian energy metabolism, especially in cold environments, as it helps maintain body temperature through non-shivering thermogenesis. The thermogenesis process of BAT is activated by norepinephrine and relies on uncoupling protein 1 (UCP1) on the inner membrane of mitochondria. By consuming the electrochemical proton gradient within the mitochondria, energy is converted into heat, thereby achieving thermogenesis function. In addition, BAT can also help prevent cardiovascular metabolic diseases and certain types of

Thu, 2024/10/17

Why Does Aging Lead to Cancer? Chronic Inflammation Is Key

Researchers from the Icahn School of Medicine at Mount Sinai have published a research paper titled "Hematopoietic aging promotes cancer by fueling IL-1⍺–driven emergency myelopoiesis" in the top international academic journal Science. This study suggests that regardless of the age of the matrix and tumor, the aging of the immune system can produce harmful inflammatory responses, thereby promoting cancer development. Blocking the inflammatory pathway (IL-1 ⍺/IL-1 β) can reverse the pro-cancer effects of aging, opening up new avenues for cancer prevention. This study provides strong

Thu, 2024/10/17

The Mechanism of MICL Regulating Neutrophil NET Formation: Providing New Ideas for the Treatment of Autoimmune Diseases

The immune system needs to control the immune response to maintain a balance between inhibiting infection and preventing excessive inflammation from damaging tissues. As the most numerous type of immune cells in the circulatory system, neutrophils play an important defense role against a large number of pathogens. At the same time, to maintain the balance of immune response, the antimicrobial response of neutrophils must be accurately regulated. Neutrophils are activated by pro-inflammatory signals and activate different effector effects based on the composition of surface receptors and endoge

Thu, 2024/10/17

The Key Role of JUN Protein in Inhibiting the Growth of Human Liver Cancer

Yes related proteins (YAP) and their homologs, transcription co-activators carrying PDZ binding motifs (TAZ), are the main downstream effectors of the Hippo signaling pathway. Recently, a research report titled "A non-canonical repressor function of JUN restrains YAP activity and liver cancer growth" was published in the journal EMBO Journal. Scientists from institutions such as the Fritz Lipmann Institute in Germany discovered an additional control mechanism that can prevent liver cancer growth through their research. In the article, researchers found that JUN protein plays a decisive role i

Wed, 2024/10/16

FOXP3 Regulation: The Unique Molecular Mechanisms behind the Occurrence of Multiple Sclerosis and Other Autoimmune Diseases

More than 20 years ago, researchers at Yale University discovered a special type of T cell in the human body that can suppress the immune system. Later, they found that when defective, these so-called regulatory T cells can trigger some autoimmune diseases, especially multiple sclerosis (MS, multiple sclerosis). For many years, the molecular mechanisms behind this functional impairment have been unclear to researchers. Recently, a research report titled "An autoimmune transcriptional circuit drives FOXP3+ regulatory T cell dysfunction" was published in the journal Science Translational Medicin

Thu, 2024/08/29

AFDN Deficiency Promotes Hepatotropism in Metastatic Colorectal Cancer

The selective metastasis of cancer cells to specific organs is a complex process that is influenced not only by anatomical factors, but also by biological and organ-specific microenvironmental factors. The pre-metastatic niche refers to the soluble factors and extracellular vesicles (EVs) produced by cells at the site of the primary tumor, which can alter the microenvironment of distant organs to accommodate migrating cancer cells and promote their growth. In addition, disseminated tumor cells (DTCs) can enter a dormant state in circulation and new tissue environments, evad

Thu, 2024/08/29

Refresh The Size Limit Of Biological Proteins! The Synthesis Mechanism of the Largest Protein Discovered So Far

In a groundbreaking study, a research team from the Scripps Institution of Oceanography at the University of California, San Diego, revealed the secret of how a microalgae called Prymnesium parvum produces complex toxins. During this process, they discovered an unprecedentedly large protein in the field of biology, named PKZILLA-1. This discovery not only broke the record for protein size, but also opened the door to new drug development and material exploration. The relevant research results were published in the Science journal, under the title “Giant polyketide syn

Thu, 2024/08/29

Ketogenic Diet Forces Pancreatic Cancer to Change Its Metabolic Mode, Exposing Fatal Flaws!

We have previously reported various anti-cancer methods of a ketogenic diet. For example, improving the sensitivity of drug-resistant cancer cells to anticancer drugs; Reducing PD-L1 levels, and enhancing the anti-cancer effect of CTLA-4 inhibitors; And the ketone body β – hydroxybutyrate produced by the ketogenic diet directly inhibits the formation and development of colon cancer, and so on. Today, a research team led by Davide Ruggero from the University of California, San Francisco published a groundbreaking study in the top journal Nature. They fo