Creative Biomart Blog

Thu, 2023/03/02

Autoimmunity in Down’s syndrome via cytokines

In a new study, researchers from the Icahn Medical College in Mount Sinai, the United States, determined which parts of the immune system of patients with Down's syndrome had problems, which led to autoimmune diseases. Relevant research results were published online in the journal Nature. This new study complements the findings of these authors published in the journal of Immunity in October 2022, that is, the frequency of viral infection in patients with Down's syndrome is lower, but more serious (Immunity, 2022, doi: 10.1016/j.immi.2022.09.007). By studying the laboratory samples of vo

Fri, 2023/02/17

The combination of PD1-IL2v and anti-PD-L1 can destroy the resistance of cancer to immunotherapy

Immunotherapy is a method of treating cancer by reprogramming the immune system of patients to attack their tumors. This cutting-edge treatment has had a significant impact on the treatment of cancer patients, and there have been cases of long-term remission. However, many patients either do not respond to immunotherapy, or even if they do, the effect is temporary, which highlights how important it is for us to better understand the mechanism that causes cancer to resist this treatment. In a new study, researchers from the Federal Institute of Technology in Lausanne, the University Hospi

Fri, 2023/02/17

The antiviral APOBEC3 protein actually promotes HIV to enter the latent state

In a new study, researchers described a discovery that violated the rules of the game in this field. Their research results show that a host protein family, which has long been considered as a pure antiviral substance, sometimes helps latent HIV find a safe harbor in patients. Understanding HIV latency at the molecular level is crucial for efforts to eliminate the virus scourge that causes immune deficiency syndrome (AIDS, commonly known as AIDS). Latent infection cell bank (also known as HIV virus bank) - HIV hides and persists in the body of infected patients in a silent standby mode - is

Fri, 2023/02/17

Restoring lost epigenetic information can make aging mammals rejuvenate

An international study lasting for 13 years has shown for the first time that the degradation of the way DNA is assembled and regulated - the so-called epigenetics - can drive the aging of organisms, and has nothing to do with the change of the genetic code itself. This study shows that the destruction of epigenetic information leads to the aging of mice, and the restoration of the integrity of the epigenome can reverse these signs of aging. The relevant research results were published online in Cell and the title of the paper was “Loss of epigenetic information as a cause of mammalian aging”.

Fri, 2023/02/17

CAR-T cell therapy is expected to eliminate residual tumor cells after solid tumor surgery

In a new preclinical study, researchers from the Perelman School of Medicine at the University of Pennsylvania found that as a method of reprogramming patients' autoimmune cells to attack their blood cancer, CAR-T cell therapy may improve the effectiveness of surgical treatment of solid tumors. The relevant research results were published in the journal Science Advances, and the title of the paper was “Chiric antigen receiver T cells as adjuvant-therapy for unresectable adenoccinoma”. In this new study, the authors applied a special gel containing human CAR-T cells to the surgical wound aft

Fri, 2022/12/23

CDK4 - a master regulator of the cell cycle

The mammalian cell cycle can be divided into four stages, namely Gap 1 (G1 stage), Synthesis (S stage), Gap 2 (G2 stage), and Mitosis (M stage). Its sequence and time are crucial for the accurate transmission of genetic information. Therefore, some biochemical pathways have evolved to ensure that the initiation of a specific cell cycle event depends on the accurate completion of another event. These biochemical pathways are called “checkpoints”. The cell cycle is partially regulated by cyclins and their related serine/threonine cyclin-dependent kinases (CDKs). When CDK4 is combined with D-t

Fri, 2022/12/23

Occluding the ACE2 receptor, renders all mutants incapable of infection!

With successive waves of uncapping, enhancing disease resistance has become one of the most important things at present. Vaccines are the most effective medicines to fight the coronavirus at the moment, and intensified vaccination is also a more desirable method. However, the Omicron virus strain has evolved an extreme ability to infect, and it is not realistic to hope for a vaccine to eliminate the infection. On the other hand, the harm to the elderly and children of Omicron remains non-negligible, and these two groups are, in turn, precisely the less immunocompromised groups, for whom vac

$Targeting PI4KA increases chemosensitivity of refractory leukemia by regulating ERK/AMPK/OXPHOS axis$

Fri, 2022/12/23

Targeting PI4KA increases chemosensitivity of refractory leukemia by regulating ERK/AMPK/OXPHOS axis

Leukemia is a highly aggressive hematological malignancy characterized by extensive molecular changes that affect clinical outcomes and provide potential drug development targets. However, the emergence of chemotherapy resistance obviously hinders the effect of chemotherapy and indicates a poor prognosis. About 15% - 30% of leukemia patients are resistant to chemotherapy, and 60% - 80% of patients with complete remission inevitably relapse and succumb to the disease. Therefore, it is very important to evaluate chemotherapy resistance in advance for treatment decision-making and prognosis. R