Creative Biomart Blog

Tue, 2025/12/23

RSV Virus Warrants Attention Beyond Influenza: Decoding the Mechanism of F and G Proteins in Cell Entry

Keywords: Respiratory syncytial virus (RSV), F protein, G protein, RSV vaccine The Critical Threat of RSV Overall, the F and G proteins are suitable targets for neutralizing antibodies in RSV vaccine design due to their important functions and genetic conservation. Respiratory syncytial virus (RSV) ranks among the three major respiratory viruses, circulating annually during winter and early spring. As an RNA virus transmitted through airborne routes, RSV poses significant health threats to children, older adults, and immunocompromised individuals. According to National Institutes of Health (NI

Tue, 2025/12/23

Cancer Cells Deploy a "Fatigue the Enemy" Strategy: Melanosomes Released by Melanoma Cells Trigger Dysfunction and Apoptosis in Anti-Tumor T Cells

Keywords: Immunotherapy, Melanoma cells, T-cell receptor (TCR), TCR sequencing (TCR-seq) Although melanoma cells often express numerous mutated proteins, infiltration of reactive T cells rarely leads to tumor eradication by the immune system. A research team led by Carmit Levy at Tel Aviv University, Israel, published an online study in Cell titled "HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion." The study discovered that large extracellular vesicles secreted by melanoma cells—called melanosomes—are decorated with major histocompatibility complex (

Tue, 2025/12/23

Dietary Supplementation Delays T-cell Exhaustion and Enhances Anti-Cancer Efficacy: Synergy with PD-1 Blockade Achieves "1+1>2" Effect

Keywords: Vitamin B6, Cancer immunotherapy, CD8+ T cells Key Discovery: Vitamin B6 Maintains T-Cell Stemness Vitamin B6, through its active form pyridoxal 5'-phosphate (PLP), directly inhibits the p70S6K kinase, preventing its phosphorylation of the BACH2 transcription factor, thereby maintaining a stem-like state in CD8⁺ T cells, delaying their exhaustion, and significantly enhancing their anti-tumor capacity. In the tumor battlefield, CD8+ T cells are like special forces operating deep behind enemy lines, tasked with identifying and destroying tumor cells. However, under prolonged, high-pres

Tue, 2025/12/23

Common Medications May Affect CRISPR Therapy and Cancer Precision Treatment Outcomes

Introduction: A New Analysis of Drug-Genome Interactions Research has identified several approved drugs as promising candidates for treating DNA repair-deficient cancers, offering potential options beyond current therapies. In a new study, scientists at the Max Planck Institute for Evolutionary Anthropology analyzed the effects of more than 2,000 clinically approved drugs on DNA repair and CRISPR genome editing outcomes. They discovered compounds that could improve genome editing, molecules that selectively kill cultured cancer cells, and further identified new functions for two proteins in DN

Tue, 2025/11/25

The "Rashomon" of Cells - Why Does the Same Virus Only Infect "You"?

Researchers have developed an ingenious method to successfully “turn back time” and glimpse the true state of cells that are destined to be infected before they “get into trouble”. Imagine a crowded room where someone sneezes and the cold virus instantly fills the air. A few days later, some people are fine, while others start to sniffle and cough. We usually attribute this to differences in individual immunity. But if we switch the scene to the microscopic world and enter a tissue composed of tens of thousands of almost identical cells, a more fundamental and puzzling

Mon, 2025/11/24

The next frontier of autoimmune diseases and cancer immunotherapy

The story of ADAR1 is a perfect example of how basic biological research can reveal the fundamental laws of life and ultimately bring revolutionary breakthroughs in the treatment of major diseases. In every cell of our body, a silent “hidden battle” is constantly taking place - the RNA in the cell sometimes forms double-stranded RNA (dsRNA) structures similar to viral RNA. If they are mistakenly judged by the immune system as “foreign invasion”, it will trigger a terrible autoimmune storm. The key to preventing this disaster is a protein called ADAR1. However, ADAR1 has

Sun, 2025/11/23

Newly Engineered Antibody Matches Low-Dose IVIG in Mouse Models

Researchers have developed a powerful upgraded therapy: an engineered antibody that achieves the therapeutic efficacy of intravenous immunoglobulin (IVIG) in mice at extremely low doses, and can be synthesized without human plasma. Intravenous immunoglobulin (IVIG) therapy treats autoimmune diseases by infusing naturally occurring IgG antibodies into patients. Dating back to the 1950s, this therapy is currently FDA-approved for only four diseases but is widely used off-label for over 80 other conditions, as it is often the only effective treatment available. However, IVIG has significant drawb

Sun, 2025/11/23

AI Designs Proteins from Scratch to Achieve Precise Mitochondrial Gene Editing

This study has developed a universal and computationally guided ultra-precise base editing method, providing a promising platform for the mechanistic study and therapeutic correction of single-base mutations. Mitochondria are crucial for cellular energy production and overall cell function. Mutations in mitochondrial DNA (mtDNA) can cause debilitating diseases, particularly affecting high-energy-consuming tissues such as muscle and nerve cells. High-precision manipulation of mtDNA holds the promise of revealing underlying disease mechanisms and providing targeted therapeutic solutions, but ach