Creative Biomart Blog

Thu, 2026/01/22

The Critical Regulatory Role of USP25 in Parkinson's Disease

Pharmacological inhibition of USP25 using the small-molecule inhibitor AZ1 significantly alleviates PD symptoms in mice, suggesting that USP25 suppression may represent a potential therapeutic strategy for PD. Parkinson's disease (PD) is a progressive neurodegenerative disorder that poses a major threat to global health. Identifying therapeutic targets for PD will facilitate more effective clinical treatments. The Wang Xu research group from Wenzhou Medical University published online in PNAS a study titled "USP25 inhibition ameliorates Parkinson’s disease by restoring mitophagy." This s

Thu, 2026/01/22

Melanosomes Act as "Decoys" to Trap Killer T Cells

Melanoma cells secrete melanosomes that carry major histocompatibility complex molecules and tumor antigens. By binding to the T-cell receptors of CD8⁺ T cells, these melanosomes induce dysfunction and apoptosis, facilitating tumor immune evasion. Inhibiting melanosome secretion can significantly enhance anti-tumor immune effects. Among skin cancers, melanoma poses a deadly threat with 100,000 new cases annually. While immunotherapy offers hope for some patients, nearly half do not respond to treatment. Even when tumors express mutant antigens recognizable by immune cells, the CD8⁺ T cells res

Thu, 2026/01/22

Inhibiting SCoR2 Enzyme Both Blocks Fat Synthesis and Promotes Fat Burning, Opening a New Path for Obesity Treatment

Scientists from Case Western Reserve University and other institutions have discovered a key enzyme called SCoR2 that acts as a "master switch" determining the fate of fat. Have you ever wondered why some people "gain weight just by drinking water" while others seem naturally "thin"? The battle with fat may be orchestrated inside cells by a key enzyme. Obesity and metabolic dysfunction–associated steatotic liver disease (MASLD) have become global health crises affecting the quality of life for hundreds of millions, while traditional weight-loss strategies often face challenges of rebound

Thu, 2026/01/22

Upstream Target of Nucleic Acid Sensors: CDK10 Suppresses Nucleic Acid Sensors-Mediated Antitumor Immunity

This study identifies CDK10 as a cancer cell-intrinsic driver of immune evasion that inhibits antitumor immunity by limiting the production of immunostimulatory nucleic acids, thereby providing a potential new target for cancer immunotherapy. Cancer immunotherapy has revolutionized cancer treatment, but many patients do not respond. Activating innate immunity offers a promising approach to enhance therapeutic efficacy, yet the signaling kinases that directly modulate this process to augment antitumor responses remain elusive. Zhang Jinfang from Wuhan University and Lei Xiaoguang from Peking Un

Tue, 2025/12/23

RSV Virus Warrants Attention Beyond Influenza: Decoding the Mechanism of F and G Proteins in Cell Entry

Keywords: Respiratory syncytial virus (RSV), F protein, G protein, RSV vaccine The Critical Threat of RSV Overall, the F and G proteins are suitable targets for neutralizing antibodies in RSV vaccine design due to their important functions and genetic conservation. Respiratory syncytial virus (RSV) ranks among the three major respiratory viruses, circulating annually during winter and early spring. As an RNA virus transmitted through airborne routes, RSV poses significant health threats to children, older adults, and immunocompromised individuals. According to National Institutes of Health (NI

Tue, 2025/12/23

Cancer Cells Deploy a "Fatigue the Enemy" Strategy: Melanosomes Released by Melanoma Cells Trigger Dysfunction and Apoptosis in Anti-Tumor T Cells

Keywords: Immunotherapy, Melanoma cells, T-cell receptor (TCR), TCR sequencing (TCR-seq) Although melanoma cells often express numerous mutated proteins, infiltration of reactive T cells rarely leads to tumor eradication by the immune system. A research team led by Carmit Levy at Tel Aviv University, Israel, published an online study in Cell titled "HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion." The study discovered that large extracellular vesicles secreted by melanoma cells—called melanosomes—are decorated with major histocompatibility complex (

Tue, 2025/12/23

Dietary Supplementation Delays T-cell Exhaustion and Enhances Anti-Cancer Efficacy: Synergy with PD-1 Blockade Achieves "1+1>2" Effect

Keywords: Vitamin B6, Cancer immunotherapy, CD8+ T cells Key Discovery: Vitamin B6 Maintains T-Cell Stemness Vitamin B6, through its active form pyridoxal 5'-phosphate (PLP), directly inhibits the p70S6K kinase, preventing its phosphorylation of the BACH2 transcription factor, thereby maintaining a stem-like state in CD8⁺ T cells, delaying their exhaustion, and significantly enhancing their anti-tumor capacity. In the tumor battlefield, CD8+ T cells are like special forces operating deep behind enemy lines, tasked with identifying and destroying tumor cells. However, under prolonged, high-pres

Tue, 2025/12/23

Common Medications May Affect CRISPR Therapy and Cancer Precision Treatment Outcomes

Introduction: A New Analysis of Drug-Genome Interactions Research has identified several approved drugs as promising candidates for treating DNA repair-deficient cancers, offering potential options beyond current therapies. In a new study, scientists at the Max Planck Institute for Evolutionary Anthropology analyzed the effects of more than 2,000 clinically approved drugs on DNA repair and CRISPR genome editing outcomes. They discovered compounds that could improve genome editing, molecules that selectively kill cultured cancer cells, and further identified new functions for two proteins in DN