Creative Biomart Blog

$Targeting PI4KA increases chemosensitivity of refractory leukemia by regulating ERK/AMPK/OXPHOS axis$

Fri, 2022/12/23

Targeting PI4KA increases chemosensitivity of refractory leukemia by regulating ERK/AMPK/OXPHOS axis

Leukemia is a highly aggressive hematological malignancy characterized by extensive molecular changes that affect clinical outcomes and provide potential drug development targets. However, the emergence of chemotherapy resistance obviously hinders the effect of chemotherapy and indicates a poor prognosis. About 15% - 30% of leukemia patients are resistant to chemotherapy, and 60% - 80% of patients with complete remission inevitably relapse and succumb to the disease. Therefore, it is very important to evaluate chemotherapy resistance in advance for treatment decision-making and prognosis. R

Fri, 2022/12/23

TRPC can significantly regulate the pathogenesis of endotoxemia

Recently, Professor Cao Wei's team from the School of Chemistry and Pharmacy of Northwest Agriculture and Forestry University published a paper entitled “TRPC channels blockade organisms endotoxic cardiac dysfunction by hamming intelligent inflammation and Ca2+ leakage” in Nature Communications. This study revealed that the classical transient receptor potential channel (TRPC) subtypes 1 and 6 can significantly regulate the cardiac inflammatory cascade reaction induced by endotoxin, thus playing a key role in endotoxemia (ETM). This study laid a theoretical foundation for the pathogenesis

Tue, 2021/09/28

New Research Finds That Secretory Gel Protein Inhibits Cancer Immunity

How does the human body fight against tumor formation? The human immune system includes many kinds of immune cells, among which type 1 conventional dendritic cells (cDC1) are essential for effective anti-tumor immunity. It can recognize tumor antigen and induce the anti-tumor immune effect of CD8 + T cells. When cDC1 is absent, CD8 + T cell-driven tumor immunity will subside, and the therapeutic effect of CD8 + T cell activator and immune checkpoint blocking inhibitor will also decline. Therefore, cDC1 abundance and CD8 + T cell infiltration are closely related to the response of cancer patien

Fri, 2021/09/24

A New Method of Rewriting the Genetic Code of Bacterial Genome Can Add Many Unnatural Amino Acids to the Protein At One Time

Almost all organisms build their proteins by combining 20 different amino acids. In order to add new amino acids to this combination, scientists have redesigned genes and other protein-building tools to produce proteins with unique chemical properties that are very helpful for the manufacture of drugs. However, this kind of research is time-consuming and laborious, and usually, only one new amino acid can be added at a time. Now, researchers are opening the floodgates to do more. They recently reported that extensive rewriting of a bacterial genome allowed them to add many new amino acids t

Wed, 2021/04/21

Foxp3 Mediates Immune Tolerance of Thymic Treg Cells through IL-2

Regulatory T (Treg) cells play an important role in the establishment and maintenance of immune tolerance. Most Treg cells express CD25 molecule, which has a high affinity with IL-2. After activation of CD25, it signals by inducing the activation of transcription factor STAT5. IL-2 plays a central role in many aspects of Treg cell biology. In addition to TCR signaling, IL-2 – STAT5 is also required to induce Foxp3 expression in Treg cells. Foxp3 is a transcription factor marker of Treg. Its continuous expression in differentiated Treg cells is necessary for the stability and function of Tre

Wed, 2021/04/21

Inhibition of TMEM16 Can Effectively Block the Production of Syncytia Induced by SARS-CoV-2 Infection

Since the outbreak of COVID-19, it still seriously affects our lives. Therefore, the research on the pathogenesis of COVID19 and the development of related drugs will help to alleviate the epidemic situation and help to make our lives return to normal as soon as possible. Previous studies have shown that COVID19 is a disease with unique characteristics, including pulmonary thrombosis, frequent diarrhea, abnormal activation of inflammatory response and alveolar edema, rapid deterioration of lung function, and so on. However, the pathological basis behind these phenomena is still elusive. In

Wed, 2021/04/21

Targeted Nucleotide Rescue Factor DNPH1 Can Improve the Sensitivity of Cancer Cells to PARP Inhibitors

Mutations in BRCA1 or BRCA2 tumor suppressor genes increase the risk of breast and ovarian cancer. In clinical practice, these cancer patients often receive targeted poly ADP ribose polymerase (PARP) inhibitors treatment. According to a recent study published in the journal Science, Stephen C. West from the Francis Crick Institute in the UK showed that inhibition of DNPH1, a protein that eliminates the cytotoxic nucleotide 5-hydroxymethyl-deoxyuridine (hmdU) monophosphate, enhances the sensitivity of BRCA deficient cells to PARP inhibitor (PARPi). Further studies revealed that the drug's letha

Mon, 2021/03/15

Scientists May Be Able To Turn Off the Key Proteins in Cancer Cells That Depend On for Survival

In a research report entitled “Specific inhibition of the Survivin – CRM1 interaction by peptide modified molecular tweezers” published in the journal Nature Communications, scientists from Eisen University in Duisburg and other institutions revealed how to turn off the “survival protein” in cancer cells through research. Proteins can control almost all the key physiological processes in the body cells. If they do not function normally and become more or less, it will lead to the occurrence of many diseases, including cancer. Therefore, related proteins may become new important targets for sci