Creative Biomart Blog

Wed, 2021/04/21

Foxp3 Mediates Immune Tolerance of Thymic Treg Cells through IL-2

Regulatory T (Treg) cells play an important role in the establishment and maintenance of immune tolerance. Most Treg cells express CD25 molecule, which has a high affinity with IL-2. After activation of CD25, it signals by inducing the activation of transcription factor STAT5. IL-2 plays a central role in many aspects of Treg cell biology. In addition to TCR signaling, IL-2 – STAT5 is also required to induce Foxp3 expression in Treg cells. Foxp3 is a transcription factor marker of Treg. Its continuous expression in differentiated Treg cells is necessary for the stability and function of Tre

Wed, 2021/04/21

Inhibition of TMEM16 Can Effectively Block the Production of Syncytia Induced by SARS-CoV-2 Infection

Since the outbreak of COVID-19, it still seriously affects our lives. Therefore, the research on the pathogenesis of COVID19 and the development of related drugs will help to alleviate the epidemic situation and help to make our lives return to normal as soon as possible. Previous studies have shown that COVID19 is a disease with unique characteristics, including pulmonary thrombosis, frequent diarrhea, abnormal activation of inflammatory response and alveolar edema, rapid deterioration of lung function, and so on. However, the pathological basis behind these phenomena is still elusive. In

Wed, 2021/04/21

Targeted Nucleotide Rescue Factor DNPH1 Can Improve the Sensitivity of Cancer Cells to PARP Inhibitors

Mutations in BRCA1 or BRCA2 tumor suppressor genes increase the risk of breast and ovarian cancer. In clinical practice, these cancer patients often receive targeted poly ADP ribose polymerase (PARP) inhibitors treatment. According to a recent study published in the journal Science, Stephen C. West from the Francis Crick Institute in the UK showed that inhibition of DNPH1, a protein that eliminates the cytotoxic nucleotide 5-hydroxymethyl-deoxyuridine (hmdU) monophosphate, enhances the sensitivity of BRCA deficient cells to PARP inhibitor (PARPi). Further studies revealed that the drug's letha

Mon, 2021/03/15

Scientists May Be Able To Turn Off the Key Proteins in Cancer Cells That Depend On for Survival

In a research report entitled “Specific inhibition of the Survivin – CRM1 interaction by peptide modified molecular tweezers” published in the journal Nature Communications, scientists from Eisen University in Duisburg and other institutions revealed how to turn off the “survival protein” in cancer cells through research. Proteins can control almost all the key physiological processes in the body cells. If they do not function normally and become more or less, it will lead to the occurrence of many diseases, including cancer. Therefore, related proteins may become new important targets for sci

Mon, 2021/03/15

“New Partner” of PD-1 Antibody: Fusion of IL-21 Improves Anti-tumor Efficacy

PD-1 inhibitors restore the activity of tumor-responsive CD8 + T cells by eliminating the inhibition induced by PD-1 and PD-L1 interaction. This therapy has brought great changes to cancer treatment, but only a few patients can benefit from this therapy. There is evidence that the lack of effective T cell activation may be one of the reasons. In a study published in nature communications, researchers from the Institute of Biophysics, the Chinese Academy of Sciences developed a fusion protein (PD-1AB21) of PD-1 antibody and IL-21, which can block the interaction between PD-1 and PD-L1 and ta

Wed, 2021/02/03

New Co-stimulatory Signal Enables CAR-T to Show Its Potential in the Treatment of Solid Tumors

Chimeric antigen receptor (CAR) expressing T cells (CAR-T therapy) is one of the major breakthroughs in the field of cancer treatment in recent years, and has achieved excellent results in the treatment of blood cancer. CAR is like a “GPS navigation system” for T cells, so that T cells can quickly locate tumor cells that are good at camouflage, so as to find and kill them. So far, two CAR-T therapies targeting CD19 have been successfully launched in the world for the treatment of B-cell malignancies. CAR-T therapy has shown great strength in the treatment of hematological malignancies, but

Wed, 2021/02/03

AIM2 Can Regulate the Normal Function of T Cells and Play a Key Role in Reducing Autoimmune Diseases

Many of the molecules in our body help our immune system stay healthy without overreacting to cause problems for our immune cells, such as autoimmune diseases. There's a molecule called AIM2 that's part of the innate immune system that fights pathogens and keeps you healthy. However, little is known about the function of AIM2 in T cell adaptive immunity, which is an immune defense against specific pathogens and health problems in our lifetime. Now, in a new study, a research team led by Dr. Jenny Ting, Professor of genetics, University of North Carolina School of medicine, and Dr. Yisong Wa

Mon, 2021/01/04

Blocking the Effect of ATM / ATR on Serine tRNA Synthetase can Reduce Tumor Growth

Most organisms need oxygen to grow and develop, even cancerous tumors. That's why in the absence of oxygen, tumors can easily grow new blood vessels, creating a new lifeline for survival. In a new study, researchers from Scripps Institute and Nankai University in China have pinpointed the molecular mechanisms that make this happen, and provided scientific insights, making it possible to develop drugs that help kill tumors and prevent their spread in the body. The related research results were recently published in the journal PLoS Biology with the title of “Phosphorylation of seryl tRNA syn