Creative Biomart Blog

Sat, 2023/07/01

Mutated TG2 Enzyme Promotes the Progression and Diffusion Mechanism of Prostate Cancer

In a new study, researchers from Nottingham Trent University in the UK identified how a specific enzyme plays a key role in making prostate cancer more invasive and difficult to treat. They found that this enzyme, called transglutaminase 2 (TG2), which is abundant in many cells of the body, is responsible for driving the process leading to the progression and spread of prostate cancer. The relevant research results have recently been published in the journal Cell Death & Disease, with the title “Canonical and truncated transglutaminase-2 regular mucin-1 expression and androgen dependence i

Fri, 2023/06/30

By Activating Oct4, Premature Aging Mouse Cells Can Recover Their Vitality

Aging seems to be an irresistible natural law, and at the same time, how to “fight aging and achieve immortality” has become an eternal research topic. Nowadays, thanks to the rapid development of biotechnology, research on anti-aging has become increasingly popular. In 2006, the team of Shinya Yamanaka of Kyoto University in Japan first reported related research on induced pluripotent stem cells (iPSC). They found that by introducing four transcription factors, Oct4, Sox2, c-Myc, and Klf4, the terminally differentiated Somatic cell can be “reprogrammed” into pluripotent stem cells, which a

Mon, 2023/05/15

Three Dimensional Structure of the Smallest Programmable Nuclease Tnpb

In a new study, professor Virginijus Šikšnys from the Life Sciences Center (VU-LSC) of Vilnius University in Lithuania and his research team cooperated with Professor Guillermo Montoya of the Novo Nordisk Foundation Protein Research Center (CPR) of the University of Copenhagen in Denmark and his research team to determine the structure of TnpB using Cryo-EM. The relevant research results were published in Nature on April 13, 2023, with the title “TnpB structure requires minimal functional core of Cas12 nuclease family”. CRISPR Cas nuclease, such as Cas9 or Cas12, also known as gene scissors

Mon, 2023/05/15

Scientists Have Screened New Serotonin Transporter Inhibitors From Over 20 Billion Molecules

Highlights •Large-library docking finds conformationally and target-selective SERT inhibitors •Cryo-EM supports the computationally predicted structure •The inhibitors are anti-depressant-like and alleviate opioid withdrawal in mice •Targeting of transporters for structure-based ligand discovery 5-hydroxytryptamine transporter (SERT) is a common target for antidepressants as it can "transport" serotonin from synapses. Transporting protein transporters is a process of "swallowing and vomiting", completed by alternating protein conformations opening outward and inward. Research has shown t

Fri, 2023/05/12

Insufficient Sleep Can Lead to Dementia, Affecting the Clearance of Toxic Proteins in the Brain and Increasing the Risk of Dementia

This study reveals how sleep deprivation affects microglia, and finds that TREM2 mediates sleep deprivation-induced microglia overactivation, and β-Amyloid protein (Aβ） deposition increases. Long-term chronic sleep deprivation regulates inflammation and the metabolic reaction of microglia and Aβ in the brain. With the accelerating pace of society and increasing work pressure, it is sometimes particularly luxurious for modern people to have a good sleep. However, a large number of studies have shown that the quality of sleep is closely related to people's physical and mental health. Takin

Fri, 2023/05/12

Molecular Mechanism of Melanoma Induced by CDK13 Mutant Protein

The RNA surveillance pathway can detect and interpret defective transcripts to ensure the fidelity of RNA. Recently, in a research report entitled "Oncogenic CDK13 mutations infinite nuclear RNA surveillance" published on the international journal Science, scientists from Howard Hughes Medical Research Institute and other institutions found a new mechanism that affects the occurrence of melanoma through research, which has a very broad and important significance for the treatment of multiple cancer patients. In the article, researchers focused on studying a protein called CDK13, which was p

Tue, 2023/04/25

Novel CAR-T Cell Therapy with Potential for Treating Human Solid Tumors

Because of the expansion and persistence of CAR-T cells, patients receiving CAR-T cells rich in memory T cells tend to have better disease control. Human memory T cells, including stem cell-like CD8+memory T cell progenitors, will become functional stem cell-like T cells (TSTEM) or dysfunctional T group cells (TPEX). Recently, a research report entitled “T STEM like CAR-T cells exhibit improved persistence and transformer control compared with conventional CAR-T cells in preclinical models” was published in the international journal Science Translational Medicine. Scientists from Melbourne Uni

Tue, 2023/04/25

PROTAC R&D to Achieve the Latest Progress

Recently, the Li Zigang/Yin Feng research group at the Shenzhen Graduate School of Peking University published a research paper titled “Targeted biomolecule regulation platform: a Split and Mix PROTAC approach” in the Journal of the American Chemical Society, reporting peptide self-assembly formed Split and Mix PROTAC (SM PROTAC), which achieved significant degradation effects on multiple targets, such as ERα, EGFR, MEK1/2, BRD2/4, CDK4/6, AR, BCR-ABL, etc. Targeted protein degradation technology (PROTAC), as an emerging protein degradation technology, has potential advantages over small mo