Creative Biomart Blog

Mon, 2019/03/04

New Study Reveals the Molecular Mechanism of Transcription Factor ‘Surveying’ The Genome of Cells

Transcription factors (TFs) are specific proteins that regulate gene expression, which can search for and bind specific regions in the entire genome to regulate gene expression. We all know that transcription factors not only bind to specific DNA sequences, but also bind non-specifically to any DNA strand. These non-specific associations can significantly increase the ability of transcription factors to find specific targets. However, researchers are not aware of how the efficiency of more than 1,500 transcription factors in the human body changes when scanning large numbers of genomes, locali

Sun, 2019/03/03

New Study Published on Science Discovered A Gene that Can Promote Sleep While Getting Sick

Humans spend nearly a third of their time sleeping, but sleep is still one of the most enduring mysteries in biology. So far, scientists don't know which genetic or molecular power is driving people to sleep. In a new study, researchers from the University of Pennsylvania's Perelman School of Medicine discovered that a gene called Nemuri increased the need for sleep by studying more than 12,000 strains of fruit flies. Related research results are published in the journal of Science. As an antimicrobial peptide (AMP), NEMURI proteins resist bacteria with their inherent antibacterial acti

Tue, 2019/02/12

Revealing the Mechanism of Cancer Cells Spreading Through Hijacking of Immune Cells in vivo

In a new study, researchers from Queen Mary College, University of London, UK, discovered that molecules released from invasive skin cancer reprogram the healthy immune cells to help spread cancer. Targeting these molecules with inhibitory drugs may help prevent this invasive skin cancer from recurring after treatment. The results of the study were published in the Cell, entitled "Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment." The researchers obtained cells from the margins of invasive melanoma in mouse

Tue, 2019/02/12

The Rhomboid Protease Breaks the "Cell Speed Limit" When Through the Cell Membrane

In a new study, researchers from Johns Hopkins University in the United States found that as a special protein that cleaves other proteins, rhomboid proteases can break the "cell speed limit" as they pass through the cell membrane. Rhomboid protease does this by distorting their surroundings, allowing them to slide quickly from one end of the cell membrane to the other. The results of the study were published in the issue of Science, entitled "Rhomboid distorts lipids to break the viscosity-imposed speed limit of membrane diffusion". The cell membrane is the phospholipid bilayer that surrou

Fri, 2019/02/01

New Breakthrough Developed A Technology that can Detect Hundreds of Proteins in A Single Blood Sample

Recently, in a research report published in the international journal Nature Nanotechnology, scientists from McGill University have developed a new technology that can detect hundreds of proteins in a single sample which is expected to be used as a fast, high-capacity and cost-effective tool for hospitals and research laboratories. Proteins in the blood provide researchers and clinicians with vital information that indicates the health of the body. Meanwhile, these biomarkers also determine whether a patient's chest pain is caused by a cardiovascular disease event or cancer. Unfortunately,

Thu, 2019/01/31

New Study Published on J Virol Reveals The Molecular Mechanism of Human T Cell Leukemia Virus Infection and Spread

Recently, research published in the Journal of Virology, scientists from the University of Minnesota developed a new strategy that is expected to block the spread of a highly infectious virus in remote areas of central Australia. Human T-cell leukemia virus type 1 (HTLV-1) infected more than 40% adults in the community, as the first human-type cancer virus discovered by scientists, HTLV-1 induces leukemia and lymphoma. “Currently, we have clarified how HTLV-1 produces viral particles to spread to other cells in the body.” said researcher Dr. Louis Mansky, “In this study, we made mutatio

Fri, 2019/01/18

The Essence of Science Journal in December 2018

1.Science: Pro-Linked Protein 2 Cutting Can Prevent Heart Failure doi:10.1126/science.aan3303; doi:10.1126/science.aav8956 Dr. Long-Sheng Song, a researcher at the University of Iowa in the United States, and his team have confirmed in a previous study that a structural protein called junctophilin-2 (JP2) is essential for the heartbeat. Heart failure is associated with this protein loss or destruction. Now, in a new study, researchers from the University of Iowa, Shanghai Jiaotong University, and Nantong University focus on JP2. They used mice as a research object, revealing that unde

Mon, 2019/01/14

J Cell Biol: How Does a Genetic Mutation Induce a Neurological Disease Such as Parkinson's?

Mutations in multiple genes are directly related to Parkinson's disease, but researchers are not sure how these mutations affect individuals with Parkinson's disease. A recent study published in The Journal of Cell Biology, in the study, scientists from Yale University focused on a genetic mutation that induced familial Parkinson's disease. They found that the gene encodes a specific protein that controls lipids transfer between organelle membranes. In the article, the researchers investigated the key role of VPS13 protein, and the dysfunction of VPS13 protein plays an important role in