Creative Biomart Blog

Sat, 2017/04/08

Body weight is determined by energy balance. When the energy intake equals energy expenditure, the body weight remains unchanged. On the other hand, the body weight grow when the energy surplus. Energy balance is critical for survival and health, and control of food intake is an integral part of this process. Excess energy intake has become a scapegoat for the obesity epidemic in developed countries. While it is responsible in a large part due to unlimited access to food, peoples’ genes play a significant role as well. Central signals as well as several hormones and circulating peptides influ

Fri, 2017/02/24

Effect of Deletion of Malic Enzyme for Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDAC) is the most common malignancy of the pancreas. PDAC is an aggressive and difficult malignancy to treat. Incidence of PDAC correlates with increasing age and therefore is an increasing problem as world population is aging. By 2030, researchers project that pancreatic cancer will become the 2nd leading cause of cancer related death in the US after lung cancer, surpassing colorectal, breast, and prostate cancer . Chromosomal region 18q21, which contains SMAD4, is homozygously deleted in a large fraction of human solid tumours, including PDAC. A recent stu

Fri, 2016/12/30

XRCC1 Mutation Is Associated With Cerebellar Ataxia

Cerebellar ataxia can occur as a result of many diseases and presents with symptoms of an inability to coordinate balance, gait, extremity and eye movements. There are many causes of cerebellar ataxia including, among others, autoimmunity to Purkinje cells or other neural cells in the cerebellum, CNS vacuities, multiple sclerosis, infection, bleeding, infarction, tumors, direct injury, toxins, genetic disorders, and an association with statin use. Inherited (genetic) forms of ataxia must be distinguished from the many acquired (non-genetic) causes of ataxia. The genetic forms of ataxia are di

Fri, 2016/11/18

How About The Biological Science Funding Going Under Trump?

After the long campaign for the White House, Donald Trump became the new president of US. With just two months before his inauguration on 20 January, he and his staff are busy vetting candidates for top government jobs and clarifying the agenda for his first few months in office. We are waiting to see how Trump realizes his statements during the campaign. The most concerning thing for us is the attitude Trump hold for science, which will affect quantities of universities and labs, and consequence effect our business. Trump has never explicitly said that he wants to reduce funding for science

Fri, 2016/11/04

Therapy in Inflammatory Bowel Diseases

Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation and dysfunction of the epithelial barrier. The primary cause of the initiation of this disease is unclear. However, it is well accepted that inflammatory responses, most likely driven by the microbiome and defective barrier function, promote a vicious cycle that leads to chronic disease. The immune system and the microbiota mutually interact to maintain homeostasis in the intestine. However, components of the microbiota can alter this balance and promote chronic inflammation, promoting intestinal tumor develop

Tue, 2016/10/18

CXCL12-CXCR4/CXCR7, Two Axes to Repress Breast Cancer

Recently, there are two articles which reported the study on CXCL12 and breast cancer. Let’s take a glance on these new results. Breast cancer (BC) remains the most frequent cancer and the major cause of cancer-associated death in women. Based on histopathological analysis commonly used in clinical practice, BC has been identified as a heterogeneous disease classified into three main subtypes: Luminal (Lum), HER2 and triple-negative (TN), which have been further confirmed and extended by gene expression profiling. Many types of cells, such as immune cells, endothelial progenitor cells and me

Fri, 2016/08/26

Akt Protein Suppressed by pVHL Protein through Proline-hydroxylation–dependent Manner

Jianping Guo et al. studied the relationship between VHL protein and Akt protein, and their published their research results on Science Magazine (Science 26 Aug 2016: Vol. 353, Issue 6302, pp. 929-932 DOI: 10.1126/science.aad5755). Here we share this wonderful article hoping to help your research applications. Don’t forget that Creative Biomart provides VHL protein and Akt protein related molecular tools for you as always. [table caption="Related Products" width="800" colwidth="80|280|180" colalign="left|left|center|center|center"] Cat. #,Product name,Source(Host),Species,Conjugate AKT1-101H

Thu, 2016/08/18

Genome-wide Association Studies for Cardiometabolic Risk Discovery: CMDs Downstream Gene-regulatory Mechanisms Exploring

Cardiovascular disease (CMDs) accounted for 17.5 million deaths in 2012. Coronary artery disease (CAD) and stroke are the primary diseases. Franzén et al. use Genome-wide Association Studies (GWAS) to identified downstream gene-regulatory mechanisms associated with risk for CMDs. They share their findings in Science Magazine (Science 19 Aug 2016: Vol. 353, Issue 6301, pp. 827-830 DOI: 10.1126/science.aad6970). Creative Biomart can provide you kinds of molecular tools such as recombinant Cardiovascular Proteins for you research application about CMDs and CADs. Here is this article for you: G