Creative Biomart Blog

Thu, 2016/08/18

Genome-wide Association Studies for Cardiometabolic Risk Discovery: CMDs Downstream Gene-regulatory Mechanisms Exploring

Cardiovascular disease (CMDs) accounted for 17.5 million deaths in 2012. Coronary artery disease (CAD) and stroke are the primary diseases. Franzén et al. use Genome-wide Association Studies (GWAS) to identified downstream gene-regulatory mechanisms associated with risk for CMDs. They share their findings in Science Magazine (Science 19 Aug 2016: Vol. 353, Issue 6301, pp. 827-830 DOI: 10.1126/science.aad6970). Creative Biomart can provide you kinds of molecular tools such as recombinant Cardiovascular Proteins for you research application about CMDs and CADs. Here is this article for you: G

Fri, 2016/08/12

Histone Deacetylase Control endochondral bone formation by Cytokine Signaling and Matrix remodeling

Histone Deacetylase regulated the chondrocyte transcriptome by modifying the chromatin landscape and controlling non-histone protein activity. Carpio et al. found that HDAC3 promotes bone growth by restricting the secretion of inflammatory factors from chondrocytes and they publish their article on Science Signalling (Sci. Signal. 09 Aug 2016: Vol. 9, Issue 440, pp. ra79 DOI: 10.1126/scisignal.aaf3273). Here we share part of this wonderful article, and Creative Biomart Provides kinds of recombinant proteins for the research applications. [table caption="Related Products" width="800" colwidth

Thu, 2016/08/04

New Target For Neurodegenerative Diseases: RIPK1 Promoting Inflammation and Necroptosis in ALS

Ito et al. found that when RIPK1-kinase dependent signaling is disrupted in mice that lack optineurin, necroptosis is inhibited and axonal pathology is reversed. They share their findings on Science Magazine (Science 05 Aug 2016: Vol. 353, Issue 6299, pp. 603-608 DOI: 10.1126/science.aaf6803). We share this articles here for that Creative BioMart can provides kinds of recombinant and native Receptor-interacting kinase 1 (RIPK1) and Optn. [table caption="Related Products" width="800" colwidth="120|280|150" colalign="left|left|center|center|center"] Cat. #,Product name,Source(Host),Species,Conj

Thu, 2016/07/28

DNA Memories: In Vivo DNA Edit over Generations of Living Cells

Here we share an article which summary a DNA edit method in living cells (Science 29 Jul 2016: Vol. 353, Issue 6298, pp. 444-445 DOI: 10.1126/science.aah4438). Creative Biomart provides kinds of molecular tools for the synthetic biology research applications using DNA. Synthetic biology uses DNA programs to add new functions into living cells. By expressing transcription factors, microbes such as Escherichia coli can be made to perform complex computational logic and pass “memories” of selected events between generations. But DNA is more than just the source code for protein expression prog

Thu, 2016/07/21

Cyclin in Tumor: Cdk5 Disruption Promotes Antitumor Immunity

R. Dixon Dorand et al. have found that Cdk5 disruption can help outcome tumor medulloblastoma. They published their research results in Science Magazine (Science 22 Jul 2016: Vol. 353, Issue 6297, pp. 399-403 DOI: 10.1126/science.aae0477), and we share this wonderful article here. By the way, Creative Biomart provides kinds of molecular tools to promote your research about tumor therapy. [table caption="Related Products" width="800" colwidth="80|180|180" colalign="left|left|center|center|center"] Cat. #,Product name,Source(Host),Species,Conjugate CDK5-3204M,Recombinant Mouse CDK5 Protein,Mam

Thu, 2016/07/14

Neural Epigenetic Regulation: Chromatin Remodeling Regulates Genes and Neural Coding

This article is published by Yue Yang in Science Magazine (Science 15 Jul 2016: Vol. 353, Issue 6296, pp. 300-305 DOI: 10.1126/science.aad4225). The authors share their findings about nucleosome remodeling and deacetylase complex (NuRD) and Chd4 in Neural Epigenetic Regulation through Chromatin Remodeling. Creative Biomart can provide some production for related research application. [table caption="Related Products" width="800" colwidth="100|280|180" colalign="left|left|center|center|center"] Cat. #,Product name,Source(Host),Species,Conjugate CHD4-2793H,Recombinant Human CHD4 protein GST-tagg

Fri, 2016/07/01

Autoimmune Diseases Therapy: Targeted by Chimeric Antigen Receptor T cells

This article is reproduced from Science Magazine (Science 01 Jul 2016: Vol. 353, Issue 6294, pp. 14 DOI: 10.1126/science.353.6294.14) Fighting autoimmunity with immune cells. In this article, the possibility of the solving some autoimmune diseases with immune cells is discussed. Autoimmune diseases share a grim similarity with cancer: People's own cells become their enemies. But a new study published online in Science reveals a happier parallel, suggesting that a therapy designed to harness the immune system to attack cancer cells may also cull the turncoat immune cells behind certain autoim

Thu, 2016/06/23

Error-correcting Reverse Transcriptase: Increase the Precision of Transcriptomics Methods with Proofreading Function

Ellefson et al. construct a reverse transcriptase using in vitro directed evolution and protein engineering from a prokaryotic DNA polymerase. This reverse transcriptase shows increased fidelity as compared to natural reverse transcriptases and increases the precision of transcriptomics methods. Ellefson et al. published their results in Science Magazine (Science 24 Jun 2016: Vol. 352, Issue 6293, pp. 1590-1593 DOI: 10.1126/science.aaf5409). The article is followed: The molecular basis for life rests on the information flow between DNA, RNA, and proteins. Early notions of a unidirectional ce