Creative Biomart Blog

Tue, 2017/06/20

Tea and Coffee Consumption in Relation to DNA Methylation

In a recent study published in Human Molecular Genetics, researchers from the University of Uppsala, found that tea consumption may lead to DNA methylation changes of some special genes in women bodies, while those genes are thought to have interactions between cancers and estrogen metabolism. As we all know, lifestyle factors, like food choices, smoking and exposure to chemicals, can alter DNA methylation and lead to changes in gene activity. In this study, the researchers investigated whether tea and coffee consumption will lead to changes in DNA methylation. Both coffee and tea has been

Fri, 2017/06/09

Market and R&D Analysis of Recombinant Protein Drugs

According to the report of Grand View Research, the demand for recombinant technology, pharmaceutical biotechnology, and DNA sequencing technology is increasing based on disease diagnosis and treatment requirement, and the global biotechnology market is expected to grow at a compound annual growth rate of 12.3%. By 2020, the market size will be $606.8 billion. Recombinant protein, a genetic engineering and cell engineering technology, produced from the creature body, has become the most important biotechnology production. Generalized recombinant protein drugs can be divided into the following

Tue, 2017/05/23

How does FGF-dependent Metabolic Control Vascular Development?

The vasculature is the earliest organ to develop. Unlike other organs it has to be functional throughout development and therefore has to constantly adapt to the changing requirements of embryogenesis. As soon as an embryo grows bigger than about 2mm it critically depends on a functional vasculature because passive diffusion is not sufficient to supply all cells with oxygen and nutrients. Similar to embryos, any tumor wanting to grow bigger than 2mm needs functional blood vessels. This will supply the tumor with oxygen and nutrients but also provides a route for the spreading of metastasis. If

Wed, 2017/05/17

Would You Accept a Pig's Heart One Day?

Imagine: your heart is failing to work, and a replacement is deadly in need. Consistently, your family waits anxiously for a call from the hospital for the found of donor. At that point, one day, the call comes. In your fervor you scarcely hear what the doctor on the flip side of the line is letting you know. There's something you ought to know, she says. The contributor is not human. It's a pig. Actually, it's not a fantasy. In 2014, scientists announced that a pig's heart had survived for more than one year after it was transplanted into a baboon, being a proof for the assumption above. Thi

Mon, 2017/04/24

Tumor Genetic Testing—Hot Point of This Year!

"Cancer is the most common genetic disease, while all cancers are derived from abnormal DNA sequences." Professor Michael Stratton, header of the Sanger Institute at the University of Cambridge, pointed out that although different cancers have different incentives and symptoms, but can all be explained by gene mutations. No matter the Human Genome Project (HGP), the Cancer Genome Project (TCGA), the 100,000-person Genome or the "Moon Shots" program of the MD Anderson Cancer Center, they all share one dream—to conquer cancer—and believe in one concept—where there is a will, there is a way. U

Sat, 2017/04/08

Body Weight, Appetite and Lipocalin

Body weight is determined by energy balance. When the energy intake equals energy expenditure, the body weight remains unchanged. On the other hand, the body weight grow when the energy surplus. Energy balance is critical for survival and health, and control of food intake is an integral part of this process. Excess energy intake has become a scapegoat for the obesity epidemic in developed countries. While it is responsible in a large part due to unlimited access to food, peoples’ genes play a significant role as well. Central signals as well as several hormones and circulating peptides influ

Fri, 2017/02/24

Effect of Deletion of Malic Enzyme for Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDAC) is the most common malignancy of the pancreas. PDAC is an aggressive and difficult malignancy to treat. Incidence of PDAC correlates with increasing age and therefore is an increasing problem as world population is aging. By 2030, researchers project that pancreatic cancer will become the 2nd leading cause of cancer related death in the US after lung cancer, surpassing colorectal, breast, and prostate cancer . Chromosomal region 18q21, which contains SMAD4, is homozygously deleted in a large fraction of human solid tumours, including PDAC. A recent stu

Fri, 2016/12/30

XRCC1 Mutation Is Associated With Cerebellar Ataxia

Cerebellar ataxia can occur as a result of many diseases and presents with symptoms of an inability to coordinate balance, gait, extremity and eye movements. There are many causes of cerebellar ataxia including, among others, autoimmunity to Purkinje cells or other neural cells in the cerebellum, CNS vacuities, multiple sclerosis, infection, bleeding, infarction, tumors, direct injury, toxins, genetic disorders, and an association with statin use. Inherited (genetic) forms of ataxia must be distinguished from the many acquired (non-genetic) causes of ataxia. The genetic forms of ataxia are di