Creative Biomart Blog

Thu, 2017/11/30

DcR3 Is the Key Factor of Endometriosis, Academia Sinica Found

Dr. Shi-Liang Hsieh and his team, from Genomics Research Center, Academia Sinica, has done years of work to find answers to inflammations. Recently, his team has confirmed that inflammation-related DcR3 protein is a key factor to enhance adhesion of endometrial cells, which in turn cause endometriosis, offering an opportunity for the treatment of endometriosis without side effects. Their findings were published in the Journal of Pathology on October 23, 2017. Endometriosis occurs in women of childbearing age and often causes severe menstrual pain. Regard to the symptoms of endometriosis, ex

Tue, 2017/10/31

The Nobel Prize in Chemistry 2017 Awarded to Three Developers of Cryo-Electron Microscopy

The Nobel Prize in Chemistry 2017 was awarded to Jacques Dubochet, Joachim Frank, and Richard Henderson for their development of Cryo-Electron Microscopy (cryo-EM), which simplified and improved the imaging of biomolecules’ structure. Did you notice, when you look at biochemical related news a certain period of time before, the pictures of the virus or other biomolecular structure just looked like the rough photos in old 3D horror games, or we say fake 3D models. But it seems to be quite different recent years? Yes, the year of 2013 is the turning point. Scientists can start with a micros

Tue, 2017/10/24

The 2017 Nobel Prize in Physiology or Medicine Announced

2017/10/02, the 2017 Nobel Prize in Physiology or Medicine jointly to Jeffrey C. Hall, Michael Rosbash and Michael W. Young for their discoveries of molecular mechanisms controlling the circadian rhythm. They will share 9 million Swedish kroner bonuses award. Jeffrey C. Hall, born in New York in 1945. 1971 received a Ph.D. from the University of Washington, 1971 to 1973 got post-doctoral position at the California Institute of Technology. In 1974 he joined the University of Brandeis. In 2002, he joined the University of Maine. Michael Rosbash, born in 1944 in Kansas City, USA. 1970 recei

Tue, 2017/10/17

Trispecific Antibodies Show Exceptional Potency Against Diverse HIV Viruses

According to the World Health Organization (WHO) statistics, in 2016, a total of about 36 million people suffering from human immunodeficiency disease in the world. Faced such a dilemma, in the efforts of scientists’ study, it seems have a breakthrough. A study on human immunodeficiency virus (HIV) antibody was published in the September 20, 2017 of the journal Science, which is an important milestone in HIV research. Researchers create am antibody with high activity and a wide range applicability based on the genetic engineering technology. It can effectively fight against type I HIV. In g

Thu, 2017/09/28

Worldwide Mortality Rates: One in Five Deaths Linked to Poor Diet

Recent study reveals: the number of deaths among children under five is decreasing. Though overall both men and women around the world are living longer, one in five deaths were linked to poor diet last year. Life expectancy in 2016 worldwide was 75.3 years for women and 69.8 for men. Japan has the highest life expectancy at 84 years and the Central African Republic has the lowest at just over 50. There are a discrepancy of more than three decades between the highest and the lowest lifespans. Agence France Presse: more than 1.6 million people in poor country died from diarrhea caused by

Sun, 2017/09/24

Cryo-EM Technique - Uncovered the Atomic Structure of a Key Alzheimer's Protein for the First Time

Tau protein abnormal deposit is one of the most important characteristics for Alzheimer. Recently, a new finding published in Nature obtained high-resolution images of those protein deposit structures caused by Alzheimer and other neurodegenerative disease for the first time. These finding can help scientists understand how these protein harmful deposit process function at the molecular level, and help develop new treatments to prevent the formation of these proteins, and thus treat Alzheimer's disease and dementia. Alzheimer is a common neurodegenerative disease, and, at pathogenesis leve

Tue, 2017/09/05

Learn FDA’s Review of Bio-similar from ABP215

ABP215 is a biosimilar drug developed by Amgen and Allergan, using Avastin (bevacizumab) as a prototype drug. Amgen filed a drug application to the FDA in November 2016. The FDA Oncologic Drugs Advisory Committee (ODAC) met on July 13, 2017, and the members voted in favor of approving the ABP215 drug application. The ABP215 is expected to become America's first Avastin bio-similar drug. Liu Shining, the research manager in TrendForce, pointed out that, in the process of FDA review biosimilar, we can see it’s quite different from the review of new drug. Biosimilar focuses more on the similarit

Fri, 2017/07/28

Antiviral Proteins Designed by Computer May Help Halt Pandemic

Bill Gates said in a speech at the Munich Security Conference that three threats are closely related to the fate of our human species: nuclear warfare, climate change and the next global pandemic. "If we are going to prepare for the worst, we should build an arsenal." The factory he mentioned is not referring to any guns or ammunition, but the vaccine, drugs and diagnostics. At present, what troubles us most are the influenza virus. According to the report of the World Health Organization, although we have vaccine, seasonal influenza is still causing millions of illness and as many as half a