Creative Biomart Blog

Thu, 2018/03/15

Cell: TBK1 Is the Blockage to Weight Loss

Highlights TBK1 operates at the intersection of energy expenditure and inflammation TBK1 deficiency attenuates HFD-induced obesity but exaggerates inflammation TBK1 represses energy expenditure by phosphorylating and inhibiting AMPK TBK1 attenuates NF-κB activation and mediates the anti-inflammatory effect of AMPK Do you ever wonder why fat body burns even fewer calories, or why dieting for weight loss always has bottlenecks? That’s because in both cases, our body tries to defend its own weight by regulating energy expenditure. Until now, how this has happened has still been a myst

Tue, 2018/02/27

Science: How Does the “Clock” Protein Work?

As we all know that the human body can function adaptively as the day and night change. And according to a new research from the Perelman School of Medicine at the University of Pennsylvania, a key protein called Rev-erb coordinates the ebb and flow of gene expression by tightening and loosening loops in chromosomes. For the past 15 years, Mitchell A. Lazar et al. have been dedicated to revealing the molecular mechanisms by which Rev-erb proteins regulate the body's molecular clock, metabolic homeostasis, and brain health. “Many studies, including this present one, point to a connection

Tue, 2018/01/30

Breakthrough! Scientists Decipher The Fifteen Years’ Unresolved Secrets of IL-23, Revealed The Key Mechanism of Autoimmune Disease!

Recently an international team led by Professor Savvas Savvides at the VIB-UGent Inflammatory Research Center revealed the key molecular mechanisms of autoimmune and inflammatory diseases including psoriasis, rheumatoid arthritis, and Crohn's disease. By focusing on the immunomodulatory factor IL-23, they found that its proinflammatory activity is strongly dependent on its receptor IL-23R for its structural activation. The research was published in Immunity recently. Psoriasis, rheumatoid arthritis, inflammatory bowel disease and multiple sclerosis have become more prevalent over the past d

Tue, 2018/01/30

Is That True, Women Are More Likely to Survive Than Men?

Current research shows that women live longer than men. And a recent study found baby girls are more likely to survive in famine, epidemics and other unfortunate circumstances, why this happened? The research found that advantage of women may have existed very early. Researchers believe that despite the small differences in gender behavior in infancy, the fact that women also have the advantage in infancy suggests that biology, at least in part, dominates this longevity of women. "Our results bring some light to reveal the gender difference in survival," said Virginia Zarulli of South

Mon, 2018/01/29

Browning of Subcutaneous White Adipose Tissue Provides Outstanding Opportunity for Treatment of Obesity

In a recent study published in the Journal of Experimental Medicine, researchers from Caroline College and other institutions studied mice to elucidate the molecular mechanism of conversion of energy-storing white fat into energy-consuming brown one. Obesity is a major health problem for the global population, affecting people of all ages and increasing the risk of many diseases in humans, including cardiovascular disease, type 2 diabetes and cancers; although obesity can trigger so much health problems, there are currently no drugs or new therapies that are effective in treating obesity an

Tue, 2018/01/23

Scary! Pressure Will Accelerate The Occurrence of Malignant Pancreatic Cancer!

In a recent study published in the journal Cancer Cell, researchers from Columbia University Medical Center found that stress may accelerate the development of pancreatic cancer by stimulating the release of "fighting or running away" hormones, β-blockers that inhibit these hormones can effectively increase the survival of cancer-bearing mouse models. In addition, researchers analyzing patients with malignant pancreatic cancer found that patients taking selective β-blockers survived two-thirds more than the former, compared with patients who did not ingest selective β-blockers. Recent studi

Wed, 2018/01/03

New Drug Resistance Mechanism Found Through Persevere Research of Prostate Cancer

Most tumor growing can stop after long-time medicine intake, and even it can become smaller or finally disappear. But what made the doctors struggling was that a few months later cancer cells gradually developed resistance and the tumor was once again deteriorating and menacing. Without good second-line anti-cancer drugs, physicians and patients really can do nothing. However, with the persevering efforts of scientists, we have the opportunity to gain the upper hand in the long-term war between human and cancer. Since androgens are the hormone that most prostate cancer cells depend on,

Mon, 2017/12/25

Interpretation of the Recent PD-1 Research Progress (Part II)

Continued 6. Nature's New Discovery: Another Unidentified Anti-cancer Approach of PD-1 / PD-L1 Antibodies doi: 10.1038/nature22396. On May 17, Nature published an online article titled "PD-1 expression by tumor-associated macrophages inhibits phagocytosis and tumor immunity", revealing the immune checkpoint inhibitors represented by the PD-1 / PD-L1 antibody can fight cancer in a completely different way. Dr. Irving Weissman, a professor of pathology and developmental biology at Stanford University School of Medicine, led the team to find that in addition to mobilizing T cells, the