Biological therapeutics, including short interfering RNA and recombinant proteins, are prone to degradation, have limited ability to cross biological membranes, and may elicit immune responses. Therefore, delivery systems for such drugs are under intensive investigation.

Natural biomacromolecules have attracted increased attention as carriers in biomedicine in recent years because of their inherent biochemical and biophysical properties including renewability, nontoxicity, biocompatibility, biodegradability, long blood circulation time and targeting ability.

The ideal carriers should be safe, efficient and have optimal bioavailability. In addition, stability, nontoxicity and non-immunogenicity, and targeting ability to a specific site are very important. Biomacromolecule-based drug carriers are nontoxic, non-immunogenic and have high drug loading content, good biocompatibility and targeting ability. Meanwhile, they are also capable of controlled and sustained drug release.

Recent advances in our understanding of the biological functions of natural-origin biomacromolecules and the progress in the study of biological drug carriers indicate that such carriers may have advantages over synthetic material-based carriers in terms of half-life, stability, safety and ease of manufacture.

Biomacromolecules used as carriers include proteins (albumin, transferrin, lipoproteins, silk fibroin, collagen, and keratin) and polysaccharides (chitosan, cyclodextrin, hyaluronic acid, heparin and pectin).

Biomacromolecule-based carriers have been reported in the form of prodrugs, drug conjugates, nanoparticles, microcapsules, hydrogels and tissue engineering scaffolds. The use of biomacromolecule-based carriers has been shown to improve the pharmacokinetics of the payloads and to reduce systemic toxicity and immunogenicity. Furthermore, the hydroxyl, amine and carboxyl groups on the chains of these biomacromolecules can be utilized for chemical modification, making them of great significance in biomedical field.

Exploiting extracellular vesicles as carriers for biological therapeutics is a promising strategy to overcome these issues and to achieve efficient delivery to the cytosol of target cells. Exosomes are a well-studied class of extracellular vesicles known to carry proteins and nucleic acids, making them especially suitable for such strategies.

Creative BioMart provides biomacromolecule drug carriers’ design and production services. Biomacromolecule drug carriers including but not limited to:

• Exosomes
• Virus-like Nanoparticles (VNPs)

Exosomes and microvesicles are naturally adapted for the transport and intracellular delivery of proteins and nucleic acids. This makes them particularly attractive for the delivery of pharmaceutical proteins and nucleic acids, such as short interfering RNA (siRNA).

A variety of smart nanomaterials with a triggered smart mechanism responding to specific stimuli have been developed. These smart nanocarriers could release drugs in response to either physical stimuli (temperature, ultrasonic, and electrochemical), chemical stimuli (pH, redox, and ionic), or biological stimuli (glucose, enzymes, and inflammation).

Our experts could design suitable drug delivery carriers according to your requirements. Creative BioMart is your reliable partner in studying of novel drug delivery systems. We will support you with superb expertise, advanced equipment, and satisfactory customer service.

Please feel free to contact us for a detailed quote or custom requirement!