Nanoparticles(NPs) based drug delivery agents, including liposomes, polymer NPs, metal NPs and protein-based NPs have the potential to provide a safe targeted delivery by encapsulating therapeutic cargo inside the particle. VNPs are self-assembled protein-based NPs derived from the coat proteins of viral caspids. They are highly uniform and easily to be expressed in bacteria. Additionally, they lack their natural genome and therefore are non-infectious.

VNPs can be classified based on the virus type, including animal virus-based, bacteriophage-based and plant virus based, etc. To improve the specificity of VNPs to intended cells and their stability while they are in the bloodstream and the interstitial space, Creative BioMart conducted significant amount of work on the surface functionalization of the VLPs. Our engineered VNPs with design flexibility and complexity have been designed for biomedical applications such as vaccines, high-contrast functional imaging, and vascular delivery of therapeutic agents.

Different types of virus-like particles used in drug delivery studies. Reprinted from Rohovie, Marcus J., et al. Bioengineering & translational medicine 2.1 (2017): 43-57.