Creative Biomart Blog

Wed, 2025/05/14

Science Journal Highlights-202501

Chinese Scientists Reveal Sexually Dimorphic Dopamine Circuit Determines Social Sex Preference in Mice Under Different Conditions doi:10.1126/science.adq7001 In a new study, researchers from Xi'an Jiaotong University, Southwest Medical University, and Liaocheng University in China identified a sexually dimorphic dopaminergic circuit in the mouse brain influencing social sex preference. They found that under survival stress, the innate preference for interacting with female mice was reversed, and both male and female mice shifted towards a preference for males. The findings were published in th

Tue, 2025/05/13

The Neuron study reveals that different neural circuits in male and female genes lead to gender differences in empathy behavior

Everyday Misunderstandings Due to Empathy Differences We’ve all seen it before:“Top 10 Classic Lines Women Hate Most from Men” What’s wrong with you again?If that’s how you want to think, I can’t help it.It’s all my fault, okay? I’m wrong, alright?You wouldn’t understand even if I explained. Whatever.I don’t know what to do either. Just drink more water....Whether intentional or not, much like how “water” is supposedly a cure-all, these responses often come off as emotionally detached.Have you ever had this kind of experie

Tue, 2025/05/13

Nature Medicine/Cell: Cerebrospinal Fluid Proteomics Brings New Hope for Precise Prediction of AD

Alzheimer’s disease (AD) is the most common neurodegenerative dementia, and accurate pathological staging is crucial for treatment trials and prognosis. The classification of AD as proposed by the National Institute on Aging and Alzheimer’s Association (NIA-AA) relies on biomarkers of Aβ protein pathology (A) and phosphorylated tau (T), yet there remains a need to develop more cost-effective and sensitive CSF biomarkers for early diagnosis and pathological staging of AD. Today, we share high-level articles published in Nature Medicine, Cell, Nature Human Behavio, Neuron, and C

Tue, 2025/05/13

A New Hot Target - PRMT5

Synthetic lethality Synthetic lethality is not a new concept. It refers to the phenomenon where the simultaneous inhibition of two non-lethal genes leads to cell death. This holds extraordinary significance in cancer treatment, as this mechanism can be leveraged to develop drugs that specifically kill cancer cells without affecting normal cells. This has sparked a global rush among researchers to develop synthetic lethality targets. Synthetic lethality Targets Currently, among synthetic lethality targets, only PARP inhibitors have multiple products approved and marketed, including blockbusters

Sun, 2025/04/13

The common types of linkers in ADC drugs and their cleavage mechanisms in vivo

ADC drugs refer to monoclonal antibodies linked to cytotoxic small molecule payloads through covalent linkers to achieve targeted drug delivery. As of now, more than 11 ADC drugs have been approved for the market. Mechanism of Targeted Therapy in ADC Drugs Traditional Mechanism The antibody binds to antigens on the surface of target cells. It enters the lysosome through endocytosis, where enzymes or acids degrade the ADC, releasing the payload. The cytotoxic payload kills the tumor cells, achieving high selectivity in anti-tumor effects. In some cases, the payload has strong permeability, all

Sun, 2025/04/13

PD-(L)1 Antibodies in Small Cell Lung Cancer (SCLC)

Nivolumab and pembrolizumab, known as the "OK duo" of immune checkpoint inhibitors, have both failed in clinical trials for small cell lung cancer (SCLC), leading to the withdrawal of their FDA accelerated approvals for this indication. Subsequent PD-L1 inhibitors, such as atezolizumab and durvalumab, achieved breakthroughs in overall survival (OS) and were approved by the FDA. In the face of robust evidence from clinical trials, a widespread, albeit informal, consensus has emerged in the medical community: PD-1 inhibitors may improve progression-free survival (PFS) in SCLC but fail to transla

Sun, 2025/04/13

Why is it said that middle-aged people find everything difficult except for gaining weight

Why is it said that “middle-aged people find everything difficult except for gaining weight”? Research has found the culprit: a significant reduction in key anti-inflammatory molecules in the EVs secreted by middle-aged people’s fat cells, leading to metabolic disorders. This study is the first to uncover why middle-aged people are more prone to obesity: as the adipose progenitor cells age, the extracellular vesicles (EVs) they secrete can no longer effectively convey anti-inflammatory signals (miR-145-5p), resulting in uncontrolled macrophages that cause adipose tissue infla

Sun, 2025/04/13

Nat Aging: A New Epigenetic Clock Reshapes the Way People Predict Biological Age

A team at Brigham and Women’s Hospital in the USA developed a new “clock” that may help uncover what contributes to aging. They’ve introduced a novel form of epigenetic clock, a machine learning model created to predict biological age from DNA structure. This new model differentiates between genes that retard aging and those accelerating it, accurately predicting biological age and assessing the efficacy of anti-aging interventions. Their findings were published online in Nature Aging, in a paper titled “Causality-enriched epigenetic age uncouples damage and adapt