Creative Biomart Blog

Fri, 2024/11/15

Can Blocking Lactate Restart Anti-Cancer T Cells?

Cancer cells excrete metabolic byproducts such as lactate into the surrounding tumor microenvironment during their growth process. Recently, researchers at the University of Pittsburgh found that these lactic acids can cause T cells (an important immune cell) to lose their anti-cancer ability. When T cells run out of energy and become functionally depleted, they take up these lactic acids, further weakening their combat effectiveness. However, when researchers blocked the protein that inputs lactate into cells, these exhausted T cells surprisingly regained their vitality, i

Fri, 2024/11/15

Small Exercises Can Greatly Reduce Blood Pressure-With Just an Additional 5 Minutes of Exercise per Day, Blood Pressure Can Be Significantly Improved

Planned exercise can lower blood pressure, which has been widely recognized. However, researchers have paid relatively little attention to the impact of casual exercise in daily life. Recently, a research report titled “Device-Measured 24-Hour Movement Behaviors and Blood Pressure: A 6-Part Compositional Individual Participant Data Analysis in the ProPASS Consortium” was published in the journal Circulation. Scientists from University College London and other institutions found that adding a small amount of exercise in daily life, such as climbing stairs or cycling, can

Fri, 2024/11/15

Why Has The Pain Treatment Of Endometriosis Been Stagnant? Can New Research Bring Breakthroughs?

Endometriosis is a common disease affecting approximately 190 million women of childbearing age, characterized by ectopic growth of tissue similar to the endometrium outside the uterine cavity, leading to severe chronic pain, infertility, and menstrual flow abnormalities. This disease has attracted much attention due to its significant impact on quality of life, but compared to other diseases with similar effects, research investment is seriously insufficient. This lack of investment has led to significant challenges in both basic research and the development of new treatme

Fri, 2024/11/15

New Mechanism of ACLY Regulating Thermogenesis and Metabolic Stress in Brown Adipose Tissue

Brown adipose tissue (BAT) plays an important role in mammalian energy metabolism, especially in cold environments, as it helps maintain body temperature through non-shivering thermogenesis. The thermogenesis process of BAT is activated by norepinephrine and relies on uncoupling protein 1 (UCP1) on the inner membrane of mitochondria. By consuming the electrochemical proton gradient within the mitochondria, energy is converted into heat, thereby achieving thermogenesis function. In addition, BAT can also help prevent cardiovascular metabolic diseases and certain types of

Thu, 2024/10/17

Why Does Aging Lead to Cancer? Chronic Inflammation Is Key

Researchers from the Icahn School of Medicine at Mount Sinai have published a research paper titled "Hematopoietic aging promotes cancer by fueling IL-1⍺–driven emergency myelopoiesis" in the top international academic journal Science. This study suggests that regardless of the age of the matrix and tumor, the aging of the immune system can produce harmful inflammatory responses, thereby promoting cancer development. Blocking the inflammatory pathway (IL-1 ⍺/IL-1 β) can reverse the pro-cancer effects of aging, opening up new avenues for cancer prevention. This study provides strong

Thu, 2024/10/17

The Mechanism of MICL Regulating Neutrophil NET Formation: Providing New Ideas for the Treatment of Autoimmune Diseases

The immune system needs to control the immune response to maintain a balance between inhibiting infection and preventing excessive inflammation from damaging tissues. As the most numerous type of immune cells in the circulatory system, neutrophils play an important defense role against a large number of pathogens. At the same time, to maintain the balance of immune response, the antimicrobial response of neutrophils must be accurately regulated. Neutrophils are activated by pro-inflammatory signals and activate different effector effects based on the composition of surface receptors and endoge

Thu, 2024/10/17

The Key Role of JUN Protein in Inhibiting the Growth of Human Liver Cancer

Yes related proteins (YAP) and their homologs, transcription co-activators carrying PDZ binding motifs (TAZ), are the main downstream effectors of the Hippo signaling pathway. Recently, a research report titled "A non-canonical repressor function of JUN restrains YAP activity and liver cancer growth" was published in the journal EMBO Journal. Scientists from institutions such as the Fritz Lipmann Institute in Germany discovered an additional control mechanism that can prevent liver cancer growth through their research. In the article, researchers found that JUN protein plays a decisive role i

Wed, 2024/10/16

FOXP3 Regulation: The Unique Molecular Mechanisms behind the Occurrence of Multiple Sclerosis and Other Autoimmune Diseases

More than 20 years ago, researchers at Yale University discovered a special type of T cell in the human body that can suppress the immune system. Later, they found that when defective, these so-called regulatory T cells can trigger some autoimmune diseases, especially multiple sclerosis (MS, multiple sclerosis). For many years, the molecular mechanisms behind this functional impairment have been unclear to researchers. Recently, a research report titled "An autoimmune transcriptional circuit drives FOXP3+ regulatory T cell dysfunction" was published in the journal Science Translational Medicin