Creative Biomart Blog

Sun, 2025/07/13

Advances in CAR-T Cell Therapy Research (II)

Nature: HIV Viral Protein Nef Empowers Novel CAR-T Cells to Create Off-the-Shelf Donor Cells Ready for Immediate Use DOI: 10.1038/s41586-025-08657-0 CAR-T cell therapy is one of the most promising new cancer therapies to emerge in recent years. It involves extracting a patient's own T cells and genetically modifying them to recognize specific targets on the surface of cancer cells. A major limitation of this autologous CAR-T cell therapy, which uses the patient's own T cells, is that the cells must be customized for each treatment. This means patients must wait for their T cells to be modified

Fri, 2025/06/06

TOP30 Best-Selling Oncology Drugs Worldwide in 2024

The current oncology drug market is at a critical period of product iteration and technological innovation. Traditional drugs, whose patents are expiring, are rapidly exiting the historical stage, while new therapeutic paradigms, fueled by emerging technologies like ADCs, are continuously reshaping the competitive landscape of the market. The oncology treatment sector has always been a focal market fiercely contested by major pharmaceutical giants. In 2024, its global market size has reached a new historical high, with the top 30 best-selling oncology drugs achieving a total sales of $147.4 bi

Fri, 2025/06/06

Scientists Uncover the Re-adenylation Role of Key Protein TENT5A in mRNA Vaccines

This research elucidates the molecular mechanisms behind the efficacy of mRNA vaccines, emphasizing the crucial role of TENT5A in enhancing mRNA stability and immune efficacy. Related Proteins In the global battle against the COVID-19 pandemic, mRNA vaccines have established a solid immune defense for humanity due to their efficient and rapid development and deployment. From Moderna to BioNTech-Pfizer, the successful application of these vaccines has not only transformed our understanding of vaccines but also inaugurated a new era for mRNA technology in the medical field. However, despite the

Thu, 2025/06/05

Analytical Methods for Human Insulin and Its Analogues（Part II）

Biological Activity Analysis Methods Time-Resolved Fluorescence Immunoassay (TRFIA) Method Principle TRFIA is an immunoassay method based on time-resolved fluorescence technology. After insulin binds to cell receptors, it triggers tyrosine phosphorylation of the receptor's β subunit. The phosphorylated group forms a complex with anti-receptor α antibodies and europium-labeled antibodies in a double-antibody sandwich manner. By adding an acidic enhancement solution, the solid-phase antibody complex is dissociated and forms a chelate with diketone and octylphosphine molecules in the e

Thu, 2025/06/05

Analytical Methods for Human Insulin and Its Analogues

With the advancement of biotechnology, an increasing number of insulin analogues have been developed. To ensure the quality and safety of these drugs, comprehensive analyses are required. This article reviews various analytical methods for human insulin and its analogues, including structural analysis, impurity analysis, and biological activity analysis. Structure of Human Insulin and Its Analogues Structure of Human Insulin Human insulin consists of two chains, A and B, comprising a total of 51 amino acids: 21 in the A chain and 30 in the B chain. The two chains are connected by two disulfide

Wed, 2025/05/14

Science Journal Highlights-202501

Chinese Scientists Reveal Sexually Dimorphic Dopamine Circuit Determines Social Sex Preference in Mice Under Different Conditions doi:10.1126/science.adq7001 In a new study, researchers from Xi'an Jiaotong University, Southwest Medical University, and Liaocheng University in China identified a sexually dimorphic dopaminergic circuit in the mouse brain influencing social sex preference. They found that under survival stress, the innate preference for interacting with female mice was reversed, and both male and female mice shifted towards a preference for males. The findings were published in th

Tue, 2025/05/13

The Neuron study reveals that different neural circuits in male and female genes lead to gender differences in empathy behavior

Everyday Misunderstandings Due to Empathy Differences We’ve all seen it before:“Top 10 Classic Lines Women Hate Most from Men” What’s wrong with you again?If that’s how you want to think, I can’t help it.It’s all my fault, okay? I’m wrong, alright?You wouldn’t understand even if I explained. Whatever.I don’t know what to do either. Just drink more water....Whether intentional or not, much like how “water” is supposedly a cure-all, these responses often come off as emotionally detached.Have you ever had this kind of experie

Tue, 2025/05/13

Nature Medicine/Cell: Cerebrospinal Fluid Proteomics Brings New Hope for Precise Prediction of AD

Alzheimer’s disease (AD) is the most common neurodegenerative dementia, and accurate pathological staging is crucial for treatment trials and prognosis. The classification of AD as proposed by the National Institute on Aging and Alzheimer’s Association (NIA-AA) relies on biomarkers of Aβ protein pathology (A) and phosphorylated tau (T), yet there remains a need to develop more cost-effective and sensitive CSF biomarkers for early diagnosis and pathological staging of AD. Today, we share high-level articles published in Nature Medicine, Cell, Nature Human Behavio, Neuron, and C