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Recombinant Human ATF3 protein, His-SUMO-tagged

Cat.No. : ATF3-23H
Product Overview : Recombinant Human ATF3, fused with His-SUMO tag, was expressed in E. coli.
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Description : This protein binds the cAMP response element (CRE) (consensus: 5"-GTGACGT[AC][AG]-3"), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.
Source : E.coli
Species : Human
Tag : His-SUMO
Form : 20mM Tris.Cl, 50mM NaCl, 20% Glycerol, pH8.0.
Molecular Mass : 38.2kDa(including fusion tag)
Protein length : 342aa(including fusion tag)
Applications : WB, ELISA, IP, antibody production, protein array
Storage : Store at -80°C and avoid repeated freeze-thaw cycles.
Gene Name : ATF3 activating transcription factor 3 [ Homo sapiens ]
Official Symbol : ATF3
Synonyms : ATF3; FLJ41705;
Gene ID : 467
mRNA Refseq : NM_001030287
Protein Refseq : NP_001025458
MIM : 603148
UniProt ID : P18847
Chromosome Location : ATF-2 transcription factor network, organism-specific biosystem; Activation of Genes by ATF4, organism-specific biosystem; Diabetes pathways, organism-specific biosystem; Direct p53 effectors, organism-specific biosystem; Disease, organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem;
Pathway : identical protein binding; protein binding; protein dimerization activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription corepressor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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