"PPM1B" Related Products

Recombinant Human PPM1B protein, His-tagged

Cat.No.: PPM1B-79H
Product Overview: Recombinant Human PPM1B, fused with N-His tag, was expressed in E. coli.
Description: Protein phosphatase 1B is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death.
Source: E.coli
Species: Human
Tag: His
Form: 20mM Tris.Cl, 50mM NaCl, 50% Glycerol, pH8.0.
Molecular Mass: 54.6kDa(including fusion tag)
Protein length: 494aa(including fusion tag)
Applications: WB, ELISA, IP, antibody production, protein array
Storage: Store at -80centigrade and avoid repeated freeze-thaw cycles.
Gene Name: PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B [ Homo sapiens ]
Official Symbol: PPM1B
Synonyms: PPM1B; protein phosphatase, Mg2+/Mn2+ dependent, 1B; protein phosphatase 1B (formerly 2C), magnesium dependent, beta isoform; protein phosphatase 1B; PP2CB; PP2CBETA; PPC2BETAX; protein phosphatase 2C; beta isoform; PP2C-beta; protein phosphatase 2C isoform beta; protein phosphatase 2C-like protein; protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform; PP2C-beta-X; MGC21657;
Gene ID: 5495
mRNA Refseq: NM_001033556
Protein Refseq: NP_001028728
MIM: 603770
UniProt ID: O75688
Chromosome Location: 2p22.1
Pathway: Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; ISG15 antiviral mechanism, organism-specific biosystem; Immune System, organism-specific biosystem; Interferon Signaling, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem;
Function: hydrolase activity; magnesium ion binding; manganese ion binding; protein binding; protein serine/threonine phosphatase activity; protein serine/threonine phosphatase activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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