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Recombinant Rat Timp1 protein, His-tagged

Cat.No. : Timp1-61R
Product Overview : Recombinant rat TIMP1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
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  • Gene Information
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Description : TIMP1, also known as metalloproteinase inhibitor 1, a tissue inhibitor of metalloproteinases, is a glycoprotein that is expressed from the several tissues of organisms. The glycoprotein is a natural inhibitor of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. MMP1 functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. It plays a role in integrin signaling.
Source : Insect cell
Species : Rat
Tag : His
Form : Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.
Molecular Mass : 22.3kDa (200aa)18-28KDa (SDS–PAGE under reducing conditions.)
AA Sequence : CSCAPTHPQT AFCNSDLVIR AKFMGSPEII ETTLYQRYEI KMTKMLKGFD AVGNATGFRF AYTPAMESLC GYVHKSQNRS EEFLIAGRLR NGNLHITACS FLVPWHNLSP AQQKAFVKTY SAGCGVCTVF PCSAIPCKLE SDSHCLWTDQ ILMGSEKGYQ SDHFACLPRN PDLCTWQYLG VSMTRSLPLA KAEAHHHHHH
Endotoxin : < 1.0 EU per 1 microgram of protein (determined by LAL method)
Purity : >90% by SDS – PAGE
Storage : Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
Concentration : 0.5mg/ml (determined by Absorbance at 280nm)
Gene Name : Timp1 TIMP metallopeptidase inhibitor 1 [ Rattus norvegicus ]
Official Symbol : Timp1
Synonyms : TIMP1; TIMP metallopeptidase inhibitor 1; metalloproteinase inhibitor 1; tissue inhibitor of metallopeptidase 1; tissue inhibitor of metalloproteinase 1; tissue inhibitor of metalloproteinases 1; Timp; TIMP-1;
Gene ID : 116510
mRNA Refseq : NM_053819
Protein Refseq : NP_446271
MIM :
UniProt ID :
Pathway : Hemostasis, organism-specific biosystem; Matrix Metalloproteinases, organism-specific biosystem; Platelet activation, signaling and aggregation, organism-specific biosystem; Platelet degranulation, organism-specific biosystem; Response to elevated platelet cytosolic Ca2+, organism-specific biosystem;
Function : enzyme inhibitor activity; metal ion binding; metalloendopeptidase inhibitor activity; metalloendopeptidase inhibitor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are the molecular consequences of dysregulated TIMP1 expression in cancer progression? 01/06/2022

Dysregulated TIMP1 expression in cancer can disrupt the balance between MMPs and TIMPs, contributing to excessive extracellular matrix degradation, invasion, and metastasis.

Can you explain the molecular role of TIMP1 in the inhibition of metalloproteinases? 06/30/2020

TIMP1 inhibits metalloproteinases by forming a complex with them, blocking their active sites and preventing the degradation of extracellular matrix components.

How does the nuclear localization of FXN contribute to its role in cellular processes? 03/02/2020

FXN's nuclear localization is associated with its involvement in DNA repair processes, influencing genomic stability and contributing to the overall cellular response to stress.

Can you explain the interplay between TIMP1 and the immune system in inflammatory processes? 07/13/2019

TIMP1 has immunomodulatory effects, influencing inflammation by regulating immune cell migration, cytokine production, and interactions with the extracellular matrix.

What is the significance of TIMP1 in tissue homeostasis and repair? 10/19/2018

TIMP1 plays a crucial role in tissue homeostasis and repair by controlling the activity of MMPs, which are involved in remodeling the extracellular matrix during physiological and pathological processes.

Customer Reviews (3)

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Reviews
04/16/2021

    The efficient delivery of this product ensured that our research timelines were met without any complications.

    08/03/2020

      Impressed by the professionalism of the customer service team—responsive and knowledgeable about the entire product range.

      12/08/2018

        This recombined protein has become a go-to in our lab due to its reliability and the precision it brings to our experiments.

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