Human Uromodulin
Cat.No. : | UMOD-1881H |
Product Overview : | Human Uromodulin was purified from Human Urine. |
- Specification
- Gene Information
- Related Products
Cat. No. : | UMOD-1881H |
Description : | Uromodulin is the most abundant protein in normal urine. Its secretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin plays a role as a constitutive inhibitor of calcium crystallization in renal fluids. Secretion of uromodulin in urine provides protection against urinary tract infections caused by uropathogenic bacteria. Defects in Uromodulin expression are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. UMOD is involved in regulating the circulating activity of cytokines as it binds to il-1, il-2 and tnf with high affinity. |
Source : | Human Urine. |
Physical Appearance : | Filtered White lyophilized (freeze-dried) powder. |
Purity : | Greater than 95.0% as determined by SDS-PAGE. |
Formulation : | The UMOD protein was lyophilized from 0.4µm filtered solution at a concentration of 0.6mg/mL containing water. |
Stability : | Lyophilized UMOD although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution UMOD should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
Gene Name : | UMOD uromodulin [ Homo sapiens ] |
Synonyms : | Uromodulin; THP; FJHN; HNFJ; THGP; HNFJ1; MCKD2; ADMCKD2; UMOD; uromucoid; Tamm-Horsfall glycoprotein; tamm-Horsfall urinary glycoprotein; uromodulin (uromucoid, Tamm-Horsfall glycoprotein); Tamm-Horsfall urinary glycoprotein |
Gene ID : | 7369 |
mRNA Refseq : | NM_001008389.1 |
Protein Refseq : | NP_001008390.1 |
MIM : | 191845 |
UniProt ID : | P07911 |
Chromosome Location : | 16p12.3 |
Function : | calcium ion binding |
Products Types
◆ Recombinant Protein | ||
Umod-602R | Recombinant Rat Umod Protein, His-tagged | +Inquiry |
UMOD-001H | Recombinant Human UMOD Protein, Myc/DDK-tagged | +Inquiry |
UMOD-9905M | Recombinant Mouse UMOD Protein, His (Fc)-Avi-tagged | +Inquiry |
UMOD-6445R | Recombinant Rat UMOD Protein, His-tagged | +Inquiry |
UMOD-599D | Recombinant Dog UMOD Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
UMOD-91P | Native Porcine UMOD | +Inquiry |
◆ Lysates | ||
UMOD-1885HCL | Recombinant Human UMOD cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (7)
Ask a questionDeficiency or mutations in UMOD can lead to kidney disorders like tubulointerstitial nephritis, affecting kidney structure and function.
UMOD plays a crucial role in regulating salt and water reabsorption in the kidneys, affecting fluid balance.
UMOD is key in maintaining kidney and urinary tract health, influencing urine concentration and kidney function.
UMOD impacts the development and progression of CKD, influencing kidney filtration and health.
UMOD contributes to the immune defense in the urinary system, protecting against infections and inflammation.
Changes in UMOD function can impact blood pressure and cardiovascular health, due to its role in kidney function and fluid balance.
UMOD affects the formation of kidney stones, potentially influencing their development and composition.
Customer Reviews (3)
Write a reviewEfficient protein purification, crucial for our research. Highly recommended.
Accurate protein structural analysis, a critical component of our investigations.
Exceptional protein expression optimization support, greatly enhances our research.
Ask a Question for All UMOD Products
Required fields are marked with *
My Review for All UMOD Products
Required fields are marked with *
Inquiry Basket