Recombinant Human Fas Ligand (TNF superfamily, member 6)

• Cat.No.: FASLG-5413H
• Product Overview: Recombinant Humansoluble FASLG contains 175 amino acid residues and comprises the TNFhomologous region of Fasl.

Specification

• Cat. No.: FASLG-5413H
• Description: FASLG is a type-II transmembraneprotein that belongs to the tumor necrosis factor (TNF) family. Its bindingwith its receptor induces apoptosis. Fas ligand/receptor interactions play animportant role in the regulation of the immune system and the progression ofcancer.
• Source: CHO cells
• Species: Human
• Form: Lyophilized withoutadditives.
• Molecular Weight: 19.9 kDa
• Purity: >98% asdetermined by SDS-PAGE analysis.
• Endotoxin Level: <0.1 ng/ug
• Biological Activity: Determined by itsability to induce cytotoxicity in Jurkat cells in the absence of anycross-linking. The EDSO for this effect is<5.0 ng/ml.
• Specific Activity: >2 x 105units/mg
• Reconstitution: Centrifuge vialprior to opening. First add sterile distilled water to the vial to fullysolubilize the protein to a concentration of 0.1-1.0 mg/ml. After completesolubilization of the protein, it can be further diluted to other aqueoussolutions.
• Storage: Store lyophilizedprotein at -20°C and reconstituted protein in working aliquots at -20°C.Avoid repeated freeze-thaw cycles.
• OfficialSymbol: FASLG

Gene Information

• Gene Name: FASLG Fas ligand (TNFsuperfamily, member 6) [ Homo sapiens ]
• Synonyms: FASLG; Fas ligand(TNF superfamily, member 6); FASL; CD178; CD95L; CD95-L; TNFSF6; APT1LG1; tumor necrosis factor ligand superfamily member 6; APTL; CD95ligand; OTTHUMP00000032708; fas antigen ligand; apoptosis antigen ligand;apoptosis (APO-1) antigen ligand 1; tumor necrosis factor (ligand)superfamily, member 6
• Gene ID: 356
• mRNA Refseq: NM_000639
• Protein Refseq: NP_000630
• MIM: 134638
• UniProt ID: P48023
• Chromosome Location: 1q23
• Pathway: Activationof Pro-Caspase 8; Africantrypanosomiasis; Allograft rejection;Apoptosis; Autoimmune thyroid disease; Calcineurin-regulatedNFAT-dependent transcription in lymphocytes; Calcium signaling in the CD4+ TCR pathway; Caspase-8 is formed from procaspase-8; Death Receptor Signalling; FoxO family signaling; Influenza A; MAPKsignaling pathway; Measles; Pathways in cancer; Type I diabetes mellitus
• Function: cytokine activity;protein binding; receptor binding; tumor necrosis factor receptor binding

Reviews

06/06/2021

The outstanding level of customer service adds extra reassurance and confidence in using the FASLG protein for my scientific investigations.

06/20/2018

the manufacturer of FASLG provides exceptional technical support, offering valuable assistance in troubleshooting and experimental design.

08/28/2017

The FASLG protein surpasses expectations in terms of quality and will undoubtedly fulfill my experimental requirements.

Q&As

Are there diagnostic tests that measure FASLG levels in clinical settings?

Yes, there are diagnostic tests that measure FASLG levels, which can provide insights into immune function and disease processes.

In what ways can the FASLG protein be targeted for therapeutic purposes?

The FASLG protein can be targeted for therapeutic purposes in cancer treatment and autoimmune disease management.

How is the FASLG protein involved in the pathogenesis of liver diseases?

Dysregulation of FASLG expression can contribute to liver injury and the progression of liver diseases such as hepatitis and liver fibrosis.

How does the FASLG protein contribute to the pathogenesis of inflammatory bowel disease?

Dysregulation of FASLG expression can impact intestinal immune homeostasis and contribute to the pathogenesis of inflammatory bowel disease.

What role does the FASLG protein play in organ transplantation?

FASLG is involved in the regulation of immune responses to transplanted organs, and its dysregulation can impact transplant outcomes.