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Active Recombinant Mouse Insulin-Like Growth Factor Binding Protein 5

Cat.No. : Igfbp5-5644M
Product Overview : RecombinantMouse Igfbp5 protein was expressed in Murine myeloma cellline. Val15-Glu271.
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Cat. No. : Igfbp5-5644M
Description : Thesuperfamily of insulin-like growth factor (IGF) binding proteins include thesix high-affinity IGF binding proteins (IGFBP) and at least four additional low-affinitybinding proteins referred to as IGFBP related proteins (IGFBP-rP). All IGFBPsuperfamily members are cysteine-rich proteins with conserved cysteineresidues, which are clustered in the amino-and carboxy-terminal thirds of themolecule. IGFBPs modulate the biological activities of IGF proteins. SomeIGFBPs may also have intrinsic bioactivity that is independent of their abilityto bind IGF proteins. Post-translational modifications of IGFBPs, includingglycosylation, phosphorylation and proteolysis, have been shown to modify theaffinities of the binding proteins to IGF.
Source : Mammalian cells
Form : Suppliedas a 0.2 um filtered solution in Acetonitrile and TFA.
N-terminalSequence : Val15
MolecularWeight : 28.9 kDa
Activity : Measuredby its ability to inhibit the biological activity of IGF-I or IGF-II on MCF-7human breast adenocarcinoma cells. The ED50 for this effect is typically 0.5-2.5μg/mL in the presence of 30 ng/mL of rmIGF-II.
Endotoxin Level : <1.0EU per 1μg of the protein by the LAL method.
SDS-PAGE : 28-38kDa triplet, reducing conditions.
Purity : >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution : 100 μg/mLin sterile PBS
Storage : Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied.1 month, 2 to 8°C under sterile conditions after reconstitution. 3months, -20 to -70°C under sterile conditions after reconstitution.
Gene Name : Igfbp5 insulin-like growthfactor binding protein 5 [ Mus musculus ]
Official Symbol : Igfbp5
Synonyms : Igfbp5; insulin-likegrowth factor binding protein 5; IGFBP-5;AI256729; AW208790; IGFBP-5P; insulin-like growth factor-binding protein 5;IBP-5; IGF-binding protein 5; Insulin-like growth factor binding protein 5, isoform CRA_a
Gene ID : 16011
mRNA Refseq : NM_010518
Protein Refseq : NP_034648
UniProt ID : Q3UQV0
Chromosome Location : 1
Pathway : Diabetes pathways;Disease; Myometrial Relaxation and Contraction Pathways; Regulation ofInsulin-like Growth Factor (IGF) Activity by Insulin-like Growth FactorBinding Proteins (IGFBPs)
Function : fibronectin binding;growth factor binding; insulin-like growth factor I binding; insulin-likegrowth factor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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