Address: 45-1 Ramsey Road, Shirley, NY 11967, USA    USA: 1-631-559-9269  1-631-448-7888   Fax: 1-631-938-8127  Europe: 44-207-048-3343   Email: info@creative-biomart.com
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Native Human Haptoglobin

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Cat.No.:
HP-4387H
Product Overview:
Human HP produced from pooled human plasma corresponding to the Mw of isotypes of HP at 86kD and 200kD.
Description:
HP is a glycoprotein which is synthesized in the liver and circulates in the blood. HP is produced typically by hepatocytes but also by other tissues: e.g. skin, lung, and kidney. It is a positive acute phase protein that binds free hemoglobin and removes it from the circulation to prevent kidney injury, and iron loss following hemolysis. The HP-hemoglobin complex is subsequently removed by the reticuloendothelial system (generally the spleen). As the reticuloendothelial system removes the HP-hemoglobin complex from the body, HP levels are reduced in hemolytic anaemias. In the course of binding hemoglobin, HP sequesters the iron inside hemoglobin, preventing iron-utilizing bacteria from benefitting from hemolysis.
Source:
Pooled human plasma
Species:
Human
Form:
Lyophilized from 0.02M NH4HCO3. May contain traces of buffer salts.
Purity:
Greater than 96.0%.
Storage:
Human HP although stable at room temperature for 3 weeks, should be stored between 2-8°C.


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Optional requirements on this protein +Expand
C-fusion   N-fusion  Non-tagged
His   GST  Fc  Others
<1.0 eu/μg   <0.1 eu/μg  <0.01 eu/μg  Not required
Monomer Isolation   Dimer Isolation   Not required
>80% by SDS-PAGE   >90% by SDS-PAGE  >95% by SDS-PAGE  Others
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45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-048-3343
FAX: 1-631-938-8127
EMAIL: info@creative-biomart.com

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