Native Human Haptoglobin

Cat.No.: HP-4387H
Product Overview: Human HP produced from pooled human plasma corresponding to the Mw of isotypes of HP at 86kD and 200kD.
Description: HP is a glycoprotein which is synthesized in the liver and circulates in the blood. HP is produced typically by hepatocytes but also by other tissues: e.g. skin, lung, and kidney. It is a positive acute phase protein that binds free hemoglobin and removes it from the circulation to prevent kidney injury, and iron loss following hemolysis. The HP-hemoglobin complex is subsequently removed by the reticuloendothelial system (generally the spleen). As the reticuloendothelial system removes the HP-hemoglobin complex from the body, HP levels are reduced in hemolytic anaemias. In the course of binding hemoglobin, HP sequesters the iron inside hemoglobin, preventing iron-utilizing bacteria from benefitting from hemolysis.
Source: Pooled human plasma
Species: Human
Form: Lyophilized from 0.02M NH4HCO3. May contain traces of buffer salts.
Purity: Greater than 96.0%.
Storage: Human HP although stable at room temperature for 3 weeks, should be stored between 2-8°C.
Gene Name: HP haptoglobin [ Homo sapiens ]
Official Symbol: HP
Synonyms: HP; haptoglobin; zonulin; binding peptide; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; haptoglobin, beta polypeptide; haptoglobin, alpha polypeptide; BP; HPA1S; HP2ALPHA2; MGC111141;
Gene ID: 3240
mRNA Refseq: NM_001126102
Protein Refseq: NP_001119574
MIM: 140100
UniProt ID: P00738
Chromosome Location: 16q22.2
Pathway: amb2 Integrin signaling, organism-specific biosystem;
Function: catalytic activity; hemoglobin binding; serine-type endopeptidase activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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