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Recombinant Human CD-21 Protein

Cat.No. : CDA083P
Product Overview : Recombinant Human CD-21 protein 1-243 a.a. expressed in E.coli,54 kDa.
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Cat. No. : CDA083P
Description : CD21, also known as CR2, C3d receptor and EBV receptor), is expressed strongly on mature B cells, follicular dentritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro. CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation.
Source : E.coli.
Presentation : 10µg/100µl Recombinant Human CD-21 protein at 100µg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.
Applications : •ELISA•Inhibition Assays •Western Blotting
Characterization : On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 54 kDa.
Storage : Store vial at -20°Cto -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Synonyms : CR2; C3DR; CD21; C3DR; Cr2; OTTHUMP00000034421; OTTHUMP00000034447; SLEB9; CD21 antigen; Complement C3d receptor; EBV receptor; Epstein-Barr virus receptor; complement component (3d/Epstein Barr virus) receptor; complement component (3d/Epstein Barr virus) receptor 2.
Synonyms : CR2; C3DR; CD21; C3DR; Cr2; OTTHUMP00000034421; OTTHUMP00000034447; SLEB9; CD21 antigen; Complement C3d receptor; EBV receptor; Epstein-Barr virus receptor; complement component (3d/Epstein Barr virus) receptor; complement component (3d/Epstein Barr virus) receptor 2.

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the potential of targeting CR2 in therapeutic interventions for immune-related disorders? 12/15/2022

Therapeutically targeting CR2 could adjust immune responses in autoimmune conditions and transplantations.

How does CR2 interact with complement pathways and what are the implications for immune response? 07/20/2021

CR2's interaction with complement pathways influences both innate and adaptive immunity, affecting phagocytosis and inflammation.

How do genetic variations in the CR2 gene affect its protein function and disease susceptibility? 12/26/2019

Genetic variations in CR2 can alter its function, affecting susceptibility to infections and autoimmunity.

What impact does CR2 have on B-cell activation and maturation? 08/02/2019

CR2 is integral in B-cell activation and maturation, influencing adaptive immunity.

How does CR2 expression influence autoimmune diseases? 04/02/2019

Changes in CR2 expression can affect immune self-tolerance, contributing to autoimmune diseases.

What factors regulate the expression of CR2 on immune cells? 08/02/2018

Cytokines and immune cell activation states regulate CR2 expression, impacting immune responses.

What is the role of CR2 protein in immune system function? 11/05/2017

CR2 facilitates B-cell activation and antigen presentation by binding to complement component C3d, enhancing antibody responses.

Customer Reviews (3)

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Reviews
02/11/2022

    Essential partner in our protein research.

    03/01/2020

      Saves time and resources in our experiments.

      11/02/2019

        Trustworthy results, crucial for decision-making.

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