Recombinant Human CD-21 Protein
Cat.No. : | CDA083P |
Product Overview : | Recombinant Human CD-21 protein 1-243 a.a. expressed in E.coli,54 kDa. |
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- Gene Information
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Cat. No. : | CDA083P |
Description : | CD21, also known as CR2, C3d receptor and EBV receptor), is expressed strongly on mature B cells, follicular dentritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro. CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation. |
Source : | E.coli. |
Presentation : | 10µg/100µl Recombinant Human CD-21 protein at 100µg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol. |
Applications : | •ELISA•Inhibition Assays •Western Blotting |
Characterization : | On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 54 kDa. |
Storage : | Store vial at -20°Cto -80°C. When stored at the recommended temperature, this protein is stable for 12 months. |
Synonyms : | CR2; C3DR; CD21; C3DR; Cr2; OTTHUMP00000034421; OTTHUMP00000034447; SLEB9; CD21 antigen; Complement C3d receptor; EBV receptor; Epstein-Barr virus receptor; complement component (3d/Epstein Barr virus) receptor; complement component (3d/Epstein Barr virus) receptor 2. |
Synonyms : | CR2; C3DR; CD21; C3DR; Cr2; OTTHUMP00000034421; OTTHUMP00000034447; SLEB9; CD21 antigen; Complement C3d receptor; EBV receptor; Epstein-Barr virus receptor; complement component (3d/Epstein Barr virus) receptor; complement component (3d/Epstein Barr virus) receptor 2. |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionTherapeutically targeting CR2 could adjust immune responses in autoimmune conditions and transplantations.
CR2's interaction with complement pathways influences both innate and adaptive immunity, affecting phagocytosis and inflammation.
Genetic variations in CR2 can alter its function, affecting susceptibility to infections and autoimmunity.
CR2 is integral in B-cell activation and maturation, influencing adaptive immunity.
Changes in CR2 expression can affect immune self-tolerance, contributing to autoimmune diseases.
Cytokines and immune cell activation states regulate CR2 expression, impacting immune responses.
CR2 facilitates B-cell activation and antigen presentation by binding to complement component C3d, enhancing antibody responses.
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