Active Native Human MUC1 Protein

• Cat.No.: MUC1-4770H
• Product Overview: Native human MUC1 protein extracted from human acites fluid.

Specification

• Description: This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.
• Source: Human Ascites Fluid
• Species: Human
• Form: Liquid
• Bio-activity: > 5,000 IU/mL (ELISA)
• Purity: Control Grade
• Applications: Controls / Calibrators / StandardsImmunoassaysClinical ChemistryAssay Development / ValidationLife ScienceTumor Markers
• Storage: At -20 centigrade.
• Storage Buffer: Solution in 1 M sodium chloride, 1% Triton™ X-100, 0.05% sodium azide, pH 7.4.

Gene Information

• Gene Name: MUC1
• Official Symbol: MUC1 mucin 1, cell surface associated [ Homo sapiens (human) ]
• Synonyms: CA 15-3; Tumor Marker 15-3; Mucin-1; MUC-1; Breast carcinoma-associated antigen DF3; Breast Tumor Antigen; MUC1; mucin 1, cell surface associated; EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC; mucin-1; H23 antigen; breast carcinoma-associated antigen DF3; cancer antigen 15-3; carcinoma-associated mucin; episialin; krebs von den Lungen-6; mucin 1, transmembrane; peanut-reactive urinary mucin; polymorphic epithelial mucin; tumor associated epithelial mucin; tumor-associated epithelial membrane antigen
• Gene ID: 4582
• mRNA Refseq: NM_001018016
• Protein Refseq: NP_001018016
• MIM: 158340
• UniProt ID: P15941