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Active Recombinant Human DPP4, His tagged

Cat.No. : DPP4-8313H
Product Overview : DPPIV Human Recombinant produced in High-5 cells is a single, glycosylated polypeptide chain containing 746 amino acids (39-766) and having a molecular mass of 86.4 kDa.DPPIV is fused to His Tag at C-terminus and purified using conventional chromatography techniques.
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Description : The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides.
Source : High-5 cells
Species : Human
Tag : His
Form : DPP4 is formulated in 20 mM Tris-HCl buffer pH-8, 100mM NaCl, 1mM EDTA and 10% glycerol.
Bio-activity : >20 Units/mg.
AA Sequence : ADP-SRKTYTLTDYLKNTYRLKLYSLRWI SDHEYLYKQENNILVFNAEYGNSSV FLENSTFDEFGHSINDYSISP DGQFILLEYNYVKQWRHSYTASYDI YDLNKRQLITEERIPNNTQWVTWSP VGHKLAYVWNNDIYVKIEPNLPSYR ITWTGKEDIIYNGITDWVYEEEVFS AYSALWWSPNGTFLAYAQFNDTEVP LIEYSFYSDESLQYPKTVRVPYPKA GAVNPTVKFFVVNTDSLSSVTNATS IQITAPASMLIGDHYLCDVTWATQE RISLQWLRRIQNYSVMDICDYDESS GRWNCLVARQHIEMSTTGWVGRFRP SEPHFTLDGNSFYKIISNEEGYRHI CYFQIDKKDCTFITKGTWEVIGIEA LTSDYLYYISNEYKGMPGGRNLYKI QLSDYTKVTCLSCELNPERCQYYSV SFSKEAKYYQLRCSGPGLPLYTLHS SVNDKGLRVLEDNSALDKMLQNVQM PSKKLDFIILNETKFWYQMILPPHF DKSKKYPLLLDVYAGPCSQKADTVF RLNWATYLASTENIIVASFDGRGSG YQGDKIMHAINRRLGTFEVEDQIEA ARQFSKMGFVDNKRIAIWGWSYGGY VTSMVLGSGSGVFKCGIAVAPVSRW EYYDSVYTERYMGLPTPEDNLDHYR NSTVMSRAENFKQVEYLLIHGTADD NVHFQQSAQISKALVDVGVDFQAMW YTDEDHGIASSTAHQHIYTHMSHFI KQCFSLP-SGRLVPRGSHHHHHH.
Purity : Greater than 95.0% as determined by Analysis by SDS-PAGE.On SDS-PAGE under denatured condition, apparent molecular weight of glycosylated DPP4 will migrate at approximately 90kDa.
Applications : Unit Definition One unit will hydrolyze mmole of p-nitroaniline per minute at pH8.0 at 37℃ using 1mM of Gly-Pro p-nitroanilde as substrate.
Notes : For research use only.
Storage : DPP4 although stable 4 ℃ for weeks, should be stored desiccated below -18 ℃. For long term storage it is recommended to add carrier protein (0. 1% HSA or BSA). Please prevent freeze/thaw cycles.
Gene Name : DPP4 dipeptidyl-peptidase 4 [ Homo sapiens ]
Official Symbol : DPP4
Synonyms : DPP4; dipeptidyl-peptidase 4; ADCP2, adenosine deaminase complexing protein 2 , CD26, dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); dipeptidyl peptidase 4; DPPIV; ADCP-2; DPP IV; dipeptidylpeptidase 4; dipeptidyl peptidase IV; T-cell activation antigen CD26; adenosine deaminase complexing protein 2; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); CD26; ADABP; ADCP2; TP103;
Gene ID : 1803
mRNA Refseq : NM_001935
Protein Refseq : NP_001926
MIM : 102720
UniProt ID : P27487
Chromosome Location : 2q23-qter
Pathway : Incretin Synthesis, Secretion, and Inactivation, organism-specific biosystem; Integration of energy metabolism, organism-specific biosystem; Metabolism, organism-specific biosystem; Protein digestion and absorption, organism-specific biosystem; Protein digestion and absorption, conserved biosystem; Regulation of Insulin Secretion, organism-specific biosystem; Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1), organism-specific biosystem;
Function : aminopeptidase activity; collagen binding; dipeptidyl-peptidase activity; peptidase activity; peptide binding; protease binding; protein binding; protein homodimerization activity; receptor activity; receptor binding; serine-type endopeptidase activity; serine-type peptidase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does DPP4 relate to diabetes? 04/17/2023

DPP4 plays a crucial role in glucose homeostasis by cleaving incretin hormones. In diabetes, inhibiting DPP4 can enhance the action of these hormones, promoting insulin release and lowering blood sugar levels.

Are there any side effects associated with DPP4 inhibitors? 01/11/2022

Common side effects of DPP4 inhibitors include respiratory and urinary tract infections, headache, and nasopharyngitis. However, they are generally well-tolerated.

What clinical applications does DPP4 have in managing type 2 diabetes? 06/12/2020

Inhibitors of DPP4 are used in the treatment of type 2 diabetes to improve glycemic control. They work by prolonging the activity of incretin hormones, such as GLP-1, which stimulate insulin secretion.

Can DPP4 inhibitors be used as a monotherapy for diabetes? 03/10/2020

DPP4 inhibitors are often used as monotherapy or in combination with other antidiabetic medications to achieve optimal glycemic control.

How do DPP4 inhibitors differ from other diabetes medications? 06/11/2016

DPP4 inhibitors work by enhancing the effects of incretin hormones, while other diabetes medications may act on insulin sensitivity, insulin release, or glucose absorption.

Customer Reviews (3)

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Reviews
09/13/2019

    Its purity and efficacy make it an ideal choice for precise and accurate analysis, allowing me to generate reliable results.

    01/27/2019

      By incorporating the DPP4 Protein into their studies, scientists can confidently conduct their research, ushering in groundbreaking discoveries and novel insights within their respective domains.

      12/14/2016

        Its exceptional purity and functionality make it an ideal choice for accurate and precise analysis, ensuring reliable and reproducible results.

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