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Active Recombinant Human PREP, His-tagged

Cat.No. : PREP-2377H
Product Overview : Recombinant Human PREP (Leu2-Pro710) fused with an N-terminal Met and 6-His tag, was expressed in Sf 21 Cells
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  • Gene Information
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Cat. No. : PREP-2377H
Description : The protein encoded by this gene is a cytosolic prolyl endopeptidase that cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Prolyl endopeptidases have been reported to be involved in the maturation and degradation of peptide hormones and neuropeptides.
Source : Sf 21 (baculovirus)
Molecular Mass : 81 kDa
Predicted N terminal : Met
Formulation : Supplied as a 0.2 µm filtered solution in MES, NaCl and Glycerol.
Purity : >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Activity : Measured by its ability to convert the substrate benzyloxycarbonyl-Gly-Pro-7-amido-4-methylcoumarin (Z-GP-AMC) to Z-Gly-Pro and 7-amino-4-methylcoumarin (AMC). The specific activity is >3,500 pmol/min/µg, as measured under the described conditions.
EndotoxinLevel : <1.0 EU per 1 μg of the protein by the LAL method.
Storage : 6 months from date of receipt, ­20 to ­70 °C as supplied. Avoid repeated freeze­thaw cycles.
OfficialSymbol : PREP
Gene Name : PREP prolyl endopeptidase [ Homo sapiens ]
Synonyms : prolyl endopeptidase; PE; PEP; MGC16060; PREP; prolyl oligopeptidase; post-proline cleaving enzyme; dJ355L5.1 (prolyl endopeptidase); Post-proline cleaving enzyme; EC 3.4.21.26
Gene ID : 5550
mRNA Refseq : NM_002726
Protein Refseq : NP_002717
MIM : 600400
UniProt ID : P48147
Chromosome Location : 6q22
Function : serine-type endopeptidase activity; serine-type peptidase activity; peptide binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Is there an association between PREP protein and cardiovascular disease? 09/15/2022

The protein may be involved in cardiovascular disease, but the specific mechanism is not fully understood, and further research is needed to validate it.

Which diseases is PREP protein associated with? 05/28/2021

PREP protein has been implicated in several diseases, including neurological disorders such as Alzheimer's disease, stroke, and Parkinson's disease.

What is the relationship between PREP protein and the development of neurodegenerative diseases? 12/14/2020

Some studies suggest that PREP protein may be involved in the development of neurodegenerative diseases, but the specific mechanism and effects need to be further studied.

What is the role of PREP protein in tumors? 11/14/2020

Studies have shown that PREP protein is abnormally expressed in some tumors, which may be related to the development and progression of tumors, but the specific role still needs to be further studied.

What is the role of PREP protein in digestive disorders? 03/29/2020

The role of PREP protein in digestive diseases is currently limited, and more research is needed to further explore its role and potential applications.

Does PREP protein have potential in the prevention of protein aggregation diseases? 03/16/2020

PREP protein can participate in the regulation of protein folding and aggregation, so it may have potential in the prevention of protein aggregation diseases.

Customer Reviews (3)

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Reviews
01/29/2022

    The safety is very high, so you can use it with confidence.

    02/28/2021

      PREP activity is maintained for a very long time and can be maintained for a long time.

      01/21/2021

        It is very resistant to pollution and is not easily polluted.

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