Recombinant Human CALCA, GST tagged

• Cat.No.: CALCA-8634H
• Product Overview: Recombinant Human CALCA (P01258-1) mature form (Ala26-Asn141), fused with the GST tag at the N-terminus, was produced in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: GST
• Form: Lyophilized from a 0.2μm filtered solution of PBS, pH 7.5
• Molecular Mass: The recombinant human PCT/GST chimera consists of 351 amino acids and has a predicted molecular mass of 40 kDa. It migrates as an approximately 38 KDa band in SDS-PAGE under reducing conditions.
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Stability: Samples are stable for up to twelve months from date of receipt at -70oC.
• Storage: Store it under sterile conditions at -20oC~-70oC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: CALCA calcitonin-related polypeptide alpha [ Homo sapiens ]
• Official Symbol: CALCA
• Gene ID: 796
• mRNA Refseq: NM_001033952
• Protein Refseq: NP_001029124
• MIM: 114130
• UniProt ID: P01258

Reviews

05/06/2022

Quality laboratory materials, on-time delivery, and the best customer service.

01/22/2021

Impressed by the product quality and quick delivery. Great job!

07/11/2019

I love their laboratory products, and the delivery is super speedy.

Q&As

What is the chemical structure of calcitonin, and how does it regulate calcium levels in the body?

CALCA is a peptide hormone. It regulates calcium levels by reducing bone resorption, which lowers blood calcium levels, and by enhancing calcium excretion by the kidneys.

How is calcitonin synthesized from the CALCA gene?

Calcitonin is synthesized from the CALCA gene through tissue-specific alternative RNA splicing of gene transcripts and cleavage of inactive precursor proteins.

What is the role of calcitonin gene-related peptide (CGRP), another product of CALCA?

CGRP functions as a vasodilator and plays a role in antimicrobial defense in addition to its role in neurovascular regulation.

How is CALCA production affected by changes in serum calcium levels?

An increase in serum calcium levels stimulates the secretion of CALCA to help reduce the excess calcium in the bloodstream.

Can you explain the relationship betweCALCA and parathyroid hormone (PTH)?

CALCA and PTH are antagonistic hormones. PTH increases blood calcium levels, whereas calcitonin reduces them. They work together to maintain calcium homeostasis.