Recombinant Human AMPK (combination of A2/B1/G1 subunits), His-tagged
Cat.No. : | PRKAA2-105H |
Product Overview : | Recombinant full-length human AMPK (combination of A2/B1/G1 subunits) was expressed by baculovirus in Sf9 insect cells using a C-terminal His tag. |
- Specification
- Gene Information
- Related Products
Description : | AMPK (A2/B1/G1) plays a key role in insulin signaling pathway and is a major therapeutic target for the treatment of diabetes. AMPK is viewed as a fuel sensor for glucose and lipid metabolism by modulating the activity of the autonomous nervous system in vivo. Short-term overexpression of a constitutively active form of AMPK in the liver leads to mild hypoglycemia and fatty liver due to increased fatty acid utilization. |
Source : | Sf9 insect cells using baculovirus |
Species : | Human |
Tag : | His |
Form : | Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. |
Molecular Mass : | ~69 kDa (A2), ~38kDa (B1), and ~40kDa (G1) |
Purity : | >90% by densitometry |
Applications : | Kinase Assay |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.1 μg/μl |
Gene Name : | PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit [ Homo sapiens ] |
Official Symbol : | PRKAA2 |
Synonyms : | PRKAA2; protein kinase, AMP-activated, alpha 2 catalytic subunit; PRKAA; 5-AMP-activated protein kinase catalytic subunit alpha-2; AMPK; AMPKa2; AMPK-alpha-2 chain; AMPK subunit alpha-2; 5-AMP-activated protein kinase, catalytic alpha-2 chain; AMPK2; |
Gene ID : | 5563 |
mRNA Refseq : | NM_006252 |
Protein Refseq : | NP_006243 |
MIM : | 600497 |
UniProt ID : | P54646 |
Chromosome Location : | 1p31 |
Pathway : | AMPK inhibits chREBP transcriptional activation activity, organism-specific biosystem; AMPK signaling, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Energy Metabolism, organism-specific biosystem; Energy dependent regulation of mTOR by LKB1-AMPK, organism-specific biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; |
Function : | AMP-activated protein kinase activity; AMP-activated protein kinase activity; ATP binding; chromatin binding; histone serine kinase activity; metal ion binding; nucleotide binding; protein binding; protein binding, bridging; protein kinase activity; protein serine/threonine kinase activity; |
Products Types
◆ Recombinant Protein | ||
PRKAA2-4328R | Recombinant Rat PRKAA2 Protein, His (Fc)-Avi-tagged | +Inquiry |
PRKAA2-7084M | Recombinant Mouse PRKAA2 Protein, His (Fc)-Avi-tagged | +Inquiry |
PRKAA2-78H | Active Recombinant Human AMPK (A2/B1/G2), GST-His-tagged | +Inquiry |
PRKAA2-4669R | Recombinant Rat PRKAA2 Protein | +Inquiry |
PRKAA2-73H | Recombinant Human PRKAA2, GST-tagged | +Inquiry |
◆ Lysates | ||
PRKAA2-1413HCL | Recombinant Human PRKAA2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (0)
Ask a questionAsk a Question for All PRKAA2 Products
Required fields are marked with *
My Review for All PRKAA2 Products
Required fields are marked with *
0
Inquiry Basket