Active Recombinant Human ICAM1, Fc-tagged
Cat.No. : | ICAM1-146H |
Product Overview : | The extracellular domain of human CD54 [ICAM-1] (aa 28-480) is fused to the N-terminus of the Fc region of a mutant human IgG1. |
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- Gene Information
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Description : | Intercellular Adhesion Molecule-1 (ICAM-1, CD54) binds the leukocyte integrins LFA-1 and Mac1. CD54 expression is weak on leukocytes, epithelial and resting endothelial cells, as well as some other cell types, but expression can be stimulated by IFN-γ, TNF-α, IL-1β and LPS. Soluble CD54 is found in a biologically active form in serum, probably as a result of proteolytic cleavage from the cell surface, and is elevated in patients with various inflammatory syndromes such as septic shock, LAD, cancer and transplantation. |
Source : | CHO Cells |
Species : | Human |
Tag : | Fc |
Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
Bio-activity : | Shows the biological function of the CD54 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain. |
Purity : | ≥98% (SDS-PAGE) |
Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Storage : | Short Term Storage: +4°C; Long Term Storage: -20°C. Avoid freeze/thaw cycles. |
Gene Name : | ICAM1 intercellular adhesion molecule 1 [ Homo sapiens ] |
Official Symbol : | ICAM1 |
Synonyms : | ICAM1; intercellular adhesion molecule 1; BB2; CD54; human rhinovirus receptor; ICAM-1; cell surface glycoprotein P3.58; major group rhinovirus receptor; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; P3.58; |
Gene ID : | 3383 |
mRNA Refseq : | NM_000201 |
Protein Refseq : | NP_000192 |
MIM : | 147840 |
UniProt ID : | P05362 |
Chromosome Location : | 19p13.3-p13.2 |
Pathway : | Adaptive Immune System, organism-specific biosystem; African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Glucocorticoid receptor regulatory network, organism-specific biosystem; |
Function : | cell surface binding; integrin binding; protein binding; receptor activity; transmembrane signaling receptor activity; |
Products Types
◆ Recombinant Protein | ||
ICAM1-14H | Active Recombinant Human ICAM1 Protein (28-480aa), C-hIgG-His-tagged | +Inquiry |
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Icam1-1204M | Recombinant Mouse Icam1 Protein, MYC/DDK-tagged | +Inquiry |
ICAM1-292H | Recombinant Human ICAM1 Protein, Fc-tagged | +Inquiry |
ICAM1-2005R | Recombinant Rhesus Macaque ICAM1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
ICAM1-1970RCL | Recombinant Rat ICAM1 cell lysate | +Inquiry |
ICAM1-2487MCL | Recombinant Mouse ICAM1 cell lysate | +Inquiry |
ICAM1-2655HCL | Recombinant Human ICAM1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, targeting ICAM1 is being explored as a potential therapeutic strategy for inflammatory diseases, with research focusing on developing ICAM1 inhibitors.
ICAM1 is upregulated during inflammation, promoting the adhesion of immune cells to the endothelium and facilitating their migration into inflamed tissues.
ICAM1 expression can be altered in cancer cells and is implicated in promoting cancer progression by facilitating tumor cell adhesion, invasion, and metastasis.
ICAM1 levels can be measured in blood or tissue samples, and elevated levels may serve as diagnostic markers for certain inflammatory diseases.
Elevated levels of ICAM1 in some diseases may serve as prognostic markers, indicating disease severity and potential outcomes.
Customer Reviews (3)
Write a reviewManufacturers may provide documentation of the protein's validation, which includes information about its purity, concentration, stability, and potential contaminants.
This can be particularly important in clinical trials to ensure accurate and reliable results.
If the need arises for larger quantities of ICAM1 protein during the later stages of clinical trials, the manufacturer can facilitate scale-up production processes to meet those requirements.
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