Recombinant Human SETD2, GST-tagged

• Cat.No.: SETD2-461H
• Product Overview: Recombinant Human SETD2 (amino acids 1418-1714), fused with with N-terminal GST tag, was expressed in an E. coli expression system.

Specification

• Description: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.
• Source: E. coli
• Species: Human
• Tag: GST
• Form: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 16 mM glutathione, 20% glycerol and 3 mM DTT.
• Molecular Mass: 60.9 kDa
• Purity: ≥ 70%
• Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
• Stability: >6 months at –80°C

Gene Information

• Gene Name: SETD2 SET domain containing 2 [ Homo sapiens (human) ]
• Official Symbol: SETD2
• Synonyms: SETD2; HYPB; SET2; HIF-1; HIP-1; KMT3A; HBP231; HSPC069; p231HBP; SET domain containing 2; histone-lysine N-methyltransferase SETD2; huntingtin yeast partner B; lysine N-methyltransferase 3A; huntingtin interacting protein 1; huntingtin-interacting protein B; NP_054878.5; EC 2.1.1.43
• Gene ID: 29072
• mRNA Refseq: NM_014159
• Protein Refseq: NP_054878
• MIM: 612778
• UniProt ID: Q9BYW2
• Chromosome Location: 3p21.31
• Pathway: Lysine degradation
• Function: histone-lysine N-methyltransferase activity; protein binding