Active Recombinant Human ICAM1, HIgG1 Fc-tagged, mutant

• Cat.No.: ICAM1-102H
• Product Overview: The extracellular domain of human CD54 [ICAM-1] (NP_000192.2)(Gln28-Glu480) is fused to the C-terminus of the Fc region of a mutant human IgG1 was expressed in CHO cell.

Specification

• Description: This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor.
• Source: CHO cells
• Species: Human
• Tag: HIgG1 Fc-tagged, mutant
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured using CTLL-s indicator cells. Specific Activity: 1-1.5 x106 Units/mg*.
• Molecular Mass: 78KDa (monomer)
• AA Sequence: Gln28-Glu480
• Endotoxin: <0.06 eu/μg as determined by lal>
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: ICAM1 intercellular adhesion molecule 1 [ Homo sapiens ]
• Official Symbol: ICAM1
• Synonyms: ICAM1; intercellular adhesion molecule 1; BB2; CD54; human rhinovirus receptor; ICAM-1; cell surface glycoprotein P3.58; major group rhinovirus receptor; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; P3.58
• Gene ID: 3383
• mRNA Refseq: NM_000201
• Protein Refseq: NP_000192
• MIM: 147840
• UniProt ID: P05362
• Chromosome Location: 19p13.3-p13.2
• Pathway: Adaptive Immune System, organism-specific biosystem; African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Glucocorticoid receptor regulatory network, organism-specific biosystem
• Function: cell surface binding; integrin binding; protein binding; receptor activity; transmembrane signaling receptor activity