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Recombinant Human EZH2, His-GST-tagged

Cat.No. : EZH2-998H
Product Overview : Recombinant Human EZH2(amino acids 2-end), fused with N-terminal His-GST tag, was expressed in a Sf9 baculovirus expression system.
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  • Gene Information
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Description : This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene.
Source : sf9 Cells
Species : Human
Tag : His-GST
Form : 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT, 16 mM glutathione and 20% Glycerol.
Molecular Mass : 114 kDa
Purity : Purity>65%
Applications : Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Storage : >6 months at –80°C
Gene Name : EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit [ Homo sapiens (human) ]
Official Symbol : EZH2
Synonyms : EZH2; enhancer of zeste homolog 2 (Drosophila); enhancer of zeste (Drosophila) homolog 2; histone-lysine N-methyltransferase EZH2; ENX 1; EZH1; KMT6; KMT6A
Gene ID : 2146
mRNA Refseq : NM_004456
Protein Refseq : NP_004447
MIM : 601573
UniProt ID : Q15910
Chromosome Location : 7q35-q36
Pathway : Cellular Senescence; Epigenetic regulation of gene expression; MicroRNAs in cancer
Function : RNA binding; histone methyltransferase activity; histone methyltransferase activity (H3-K27 specific)

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How is EZH2 overexpression associated with cancer progression? 11/20/2019

EZH2 overexpression is associated with promoting tumor cell proliferation, invasion, and metastasis, leading to cancer progression.

Are there any non-oncological clinical applications of EZH2? 07/29/2019

EZH2 has been implicated in various non-oncological conditions, including cardiovascular diseases and neurodegenerative disorders.

What are the potential side effects of EZH2 inhibitors in clinical use? 03/15/2017

Potential side effects may include hematological toxicity, gastrointestinal issues, and liver enzyme elevation.

How can EZH2 be targeted for cancer therapy? 08/17/2016

Small molecule inhibitors of EZH2 have been developed and are being investigated as potential cancer therapies.

Are there any prognostic implications of EZH2 expression in cancer patients? 08/15/2016

High EZH2 expression has been associated with poor prognosis in several cancer types.

Customer Reviews (3)

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Reviews
10/17/2022

    The versatility of the EZH2 protein is truly remarkable, as it can be employed across a wide range of applications in my research.

    03/14/2018

      In addition to its outstanding quality, the manufacturer of the EZH2 protein offers excellent technical support that can effectively address any challenges I may encounter.

      02/27/2018

        Their dedicated team of experts is readily available to provide guidance and assistance, ensuring a seamless integration of the EZH2 protein into my experimental setup.

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