Mitotic checkpoint serine/threonine-protein kinase BUB1

Cat. No.

CBCRY01

Background

The kinase(BUB1) functions in part by phosphorylating a member of the miotic checkpoint complex and activating the spindle checkpoint. Mutations in this gene have been associated with aneuploidy and several forms of cancer.

Molecular description

Protein Classification

Transferase

Structure Weight

42450.29 Da

Polymer

1

Molecule

Mitotic checkpoint serine/threonine-protein kinase BUB1

Chain Length

365 amino acids

Crystal Description

PDB ID

3E7E

MMDB ID

68144

Source

Spodoptera frugiperda

Method

X-Ray Diffraction

Resolution

2.31 Å

Ligand Chemical Component

Adenosine-5"-triphosphate; chloride ion; Magnesium ion

Gene information

Gene Name

BUB1

Synonyms

BUB1A, BUB1L, hBUB1, BUB1 budding uninhibited by benzimidazoles 1 homolog; budding uninhibited by benzimidazoles 1; mitotic spindle checkpoint kinase; putative serine/threonine-protein kinase

UniProt ID

O43683

GeneID

699

Chromosome  Location

2q14

Function

nucleotide binding; protein kinase activity; protein serine/threonine kinase activity ; ATP binding; kinase activity; transferase activity

Reference

Kang J, Yang M, Li B, Qi W, Zhang C, Shokat KM, Tomchick DR, Machius M, Yu H. Structure and substrate recruitment of the human spindle checkpoint kinase Bub1.Mol Cell. 2008 Nov 7;32(3):394-405.