Mad2-p31(comet) complex
| Cat.No. : | CBCRY03 |
- Specification
- Gene Information
- Related Products
| Cat. No. : | CBCRY03 |
| Background : | The crystal structure of the Mad2-p31(comet) complex is reported. The C-terminal region of Mad2 that undergoes rearrangement in different Mad2 conformers is a major structural determinant for p31(comet) binding, explaining the specificity of p31(comet) toward Mad1- or Cdc20-bound Mad2. p31(comet) adopts a fold strikingly similar to that of Mad2 and binds at the dimerization interface of Mad2. Thus, p31(comet) exploits the two-state behavior of Mad2 to block its activation by acting as an "anti-Mad2." |
| Protein Classification : | cell cycle |
| Structure Weight : | 105471.24 Da |
| Polymer : | 1 |
| Molecule : | Mitotic spindle assembly checkpoint protein MAD2A |
| Chain Length : | 210 amino acids |
| PDB ID : | 2QYF |
| Source : | E.coli |
| Method : | X-Ray Diffraction |
| Resolution : | 2.30 Å |
| Modified residues : | selenomethionine (pareint: MET) |
| Reference : | Yang, M., Li, B., Tomchick, D.R., Machius, M., Rizo, J., Yu, H., Luo, X. p31comet blocks Mad2 activation through structural mimicry.Cell(Cambridge,Mass.)2007; 131: 744-755 |
| Gene Name : | MAD2L1 |
| Synonyms : | HSMAD2; MAD2; MAD2 (mitotic arrest deficient, yeast, homolog)-like 1; MAD2-like 1; MAD2-like protein 1; mitotic arrest deficient, yeast, homolog-like 1 |
| UniProt ID : | Q13257 |
| Chromosome Location : | 4q27 |
| Function : | protein binding |
| Gene ID : | 9587 |
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