Phosphoglycerate Mutase 1
Cat.No. : | CBCRY11 |
- Specification
- Gene Information
- Related Products
Cat. No. : | CBCRY11 |
Background : | The B-type cofactor-dependent phosphoglycerate mutase (dPGM-B) catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate in glycolysis and gluconeogenesis pathways using 2,3-bisphosphoglycerate as the cofactor. The crystal structures of human dPGM-B bound with citrate were determined in two crystal forms. These structures reveal a dimerization mode conserved in both of dPGM and BPGM (bisphosphoglycerate mutase), based on which a dPGM/BPGM heterodimer structure is proposed. Structural comparison supports that the conformational changes of residues 13-21 and 98-117 determine PGM/BPGM activity differences. |
Protein Classification : | isomerase hydrase |
Structure Weight : | 361525.84 |
Polymer : | 1 |
Molecule : | Phosphoglycerate mutase 1 |
Chain Length : | 262 amino acids |
PDB ID : | 1YJX |
MMDB ID : | 33356 |
Source : | E.coli |
Method : | X-Ray Diffraction |
Resolution : | 2.8? |
Ligand Chemical Component : | citric acid; chloride ion |
Reference : | Wang, Y., Wei, Z., Liu, L., Cheng, Z., Lin, Y., Ji, F., Gong, W.(2005) Crystal structure of human B-type phosphoglycerate mutase bound with citrate. Biochem.Biophys.Res.Commun. 331: 1207-1215 |
Gene Name : | PGAM1 |
Synonyms : | PGAMA; PGAM-B; PGAM1; RP11-452K12.8; OTTHUMP00000020190; OTTHUMP00000059414; phosphoglycerate mutase A, nonmuscle form; EC 5.4.2.1,EC 5.4.2.4,EC 3.1.3.13; BPG-dependent PGAM 1; Phosphoglycerate mutase isozyme B; phosphoglycerate mutase A, nonmuscle form |
UniProt ID : | P18669 |
Gene ID : | 5223 |
Chromosome Location : | 10q25.3 |
Function : | bisphosphoglycerate 2-phosphatase activity; bisphosphoglycerate mutase activity; hydrolase activity; isomerase activity; phosphoglycerate mutase activity; protein kinase binding |
Products Types
◆ Recombinant Protein | ||
Pgam1-4815M | Recombinant Mouse Pgam1 Protein, Myc/DDK-tagged | +Inquiry |
PGAM1-1656H | Recombinant Human PGAM1 Protein, His (Fc)-Avi-tagged | +Inquiry |
PGAM1-0574H | Recombinant Human PGAM1 Protein (M1-K254), Tag Free | +Inquiry |
PGAM1-0575H | Recombinant Human PGAM1 Protein (M1-K254), His/Strep tagged | +Inquiry |
PGAM1-3204R | Recombinant Rhesus Macaque PGAM1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
PGAM1-3264HCL | Recombinant Human PGAM1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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