Recombinant Human Growth Differentiation Factor 6
| Cat.No. : |
GDF6-19H |
| Product Overview : |
Recombinant HumanGDF6 produced inE.coliwas a 27.0kDa homodimeric disulfide-linked protein consisting of two 120 amino acid polypeptide chains.This 27.5kDa protein is obtained by proteolytic processing of a biologically inactive precursor protein of 97.7kDa. |
- Specification
- Gene Information
- Related Products
| Cat. No. : |
GDF6-19H |
| Description : |
BMP-13 is expressed in hypertrophic chondrocytes during embryonic development of long bones. Continued postnatal expression of BMP-13 in articular cartilage suggests that it plays a regulatory role in the growth and maintenance of articular cartilage. Adenovirus-mediated BMP-13 gene transfer to rabbit bone marrow stem cells have been reported to augment periosteal repair of osteochondral defects. The functional form of BMP-13/CDMP-2 is a disulfide-linked homodimer of two 120 amino acid polypeptide chains. |
| Source : |
E.coli. |
| Purity : |
>95% by SDS-PAGE. |
| Endotoxin Level : |
<0.1ng/μg of BMP-13. |
| Stabilizer : |
None. |
| Formulation : |
Lyophilized. |
| Biologically Activity : |
The ED50was determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells in the range of 2.0-3.0μg/ml. |
| Reconstitution : |
The human BMP-13 should be reconstituted in water to a concentration of 0.1-1.0mg/ml. This solution can be diluted in water or other buffer solutions or stored at -20°C. |
| Stability : |
The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted human BMP-13 should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles. |
| Gene Name : |
GDF6 growth differentiation factor 6 [ Homo sapiens ] |
| Synonyms : |
GDF6; growth differentiation factor 6; KFSL; KFS; GDF16; SGM1; BMP13; CDMP2; MCOP4; SCDO4; MGC158100; MGC158101; Growth/differentiation factor 6; Growth/differentiation factor 16 |
| Gene ID : |
392255 |
| mRNA Refseq : |
NM_001001557.2 |
| Protein Refseq : |
NP_001001557.1 |
| MIM : |
601147 |
| UniProt ID : |
Q6KF10 |
| Chromosome Location : |
8q22.1 |
| Pathway : |
Cytokine-cytokine receptor interaction; TGF-beta signaling pathway |
| Function : |
cytokine activity; growth factor activity |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
