Recombinant Human CDC-like Kinase 2, GST-tagged, Active

• Cat.No.: CLK2-285H
• Product Overview: Recombinant human CLK2 (137-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. MW=68 kDa.

Specification

• Cat. No.: CLK2-285H
• Description: CDC-like kinase 2 (CLK2) a family of autophosphorylating kinases termed CLK (CDC2/CDC28-like kinases) was shown to phosphorylate SR proteins and to influence alternative splicing in overexpression systems. Recent findings demonstrated that the CLK kinases activate PTP-1B family members, and this phosphatase may be an important cellular target for CLK action. Mutations in the clk-2 proteins affect organismal features such as development, behavior, reproduction, and aging as well as cellular features such as the cell cycle, apoptosis, the DNA replication checkpoint, and telomere length.
• Source: Sf9 insect cellsusing baculovirus.
• Sequence: 137-end.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70^oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: CLK2 CDC-like kinase 2 [ Homo sapiens ]
• Synonyms: CLK2; CDC-like kinase 2; hCLK2; MGC61500; CLK kinase; CLK kinase; dual specificity protein kinase CLK2; EC 2.7.12.1
• Gene ID: 1196
• mRNA Refseq: NM_003993
• Protein Refseq: NP_003984
• MIM: 602989
• UniProt ID: P49760
• Chromosome Location: 1q21
• Function: ATP binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein serine/threonine kinase activity; transferase activity